This project was started when an unknown peak was being detected in the organic volatile impurity (OVI) analysis (using the head-space vapor sampling procedure) of bortezomib (BZB) active pharmaceutical ingredient (API), in pharmaceutical companies. During the OVI analysis of the API of BZB, a huge-area peak with an unknown source appeared in the chromatograms of the gas chromatography with flame ionization detector (GC-FID). The data prepared by GC-MAS revealed that the considered huge peak was 3-methylbutanal (3MBut). But, investigating the synthesis procedures showed that during all the synthesis steps, 3MBut or any other solvent containing this impurity was not being applied. Thus, we had concluded that there is a possibility for emergence of this aldehyde from bortezomib itself. To find out which part of bortezomib might turn into 3MBut, we began to investigate all its molecular structure, and hypothesized that the α-amino-boronic acid part of the molecule turned into 3MBut. The experimental analysis and theoretical quantum chemical calculations confirmed that the α-amino-boronic acid center of bortezomib molecule undergoes a rare and unexpected aerobic oxidation by O2 molecule, even in catalyst and solvent-free conditions. The result of this project not only might make clear the passive source of the 3MBut peak of the OVI of bortezomib, but also, it would suggest to store this API in an inert oxygen-free atmosphere to improve the long-term and accelerated (thermal) stability of this very expensive anti-cancer drug.

Flibanserin (Addyi) is a medication used to treat women who have not gone through menopause who have low sexual desire. Specific and simple stability indicating method was developed and validated by high-performance liquid chromatography (RP-HPLC) for the determination of Flibanserin. Separation was carried out by using a mobile phase consisting of 0.01M Potassium phosphate monohydrate buffer (KH₂PO₄) pH 3.50 buffer: Acetonitrile in the ratio of 60:40. The column used was Agilent C18, (150×4.6) mm, 5µm with a flow rate of 1.0ml/min and temperature at 30°C. The detection was carried out at 248 nm and Flibanserin was eluted at around 2.8min. This method was validated as per ICH guidelines and validation included specificity, precision, linearity, accuracy, forced degradation, and robustness. Forced degradation was conducted under the conditions of hydrolysis, oxidation, thermal, acid, base, and peroxide hydrolysis. The calibration curve was linear over the concentration range from 20 to 200µg/mL and the coefficient of determination (r²) was observed as 0.9998. The precision and accuracy of the method were within the acceptable range. The results of this study showed that the validated method is simple and accurate, which confirmed that the method is suitable for the determination of Flibanserin.

The present manuscript describes an in-depth analysis of various interactions present in the crystal structure of formyl coumarins using Crystal explorer 17.0. Element based interactions were quantified by the decomposition of generated 3D surfaces into 2D fingerprint regions. DFT methods were used to explore electrostatic parameters, global and local reactivity descriptors. Electrophilicity based charge transfer (ECT) analysis was done to explore the probability of charge transfer between formyl coumarins and DNA base pairs. The reactivity and selectivity of different formyl coumarins have been accessed using Fukui functions in their reduced form. Non-bonding orbital (NBO) analysis revealed the presence of various hyperconjugative interactions and their stabilization energy in formyl coumarins. Non-linear optical properties are presented in terms of first order hyperpolarizibility (β₀), where maximum β₀ is observed for C4 (1.64 × 10-30esu.) which is found to be 2 times greater than that of p-nitroaniline. Molecular electrostatic potential (MEP) plots are mapped in terms of electron density.

Field experiments were carried out at Shandaweel Agricultural Research Station, Sohag, Egypt to study the effects of deficit irrigation and harvesting date chemical composition of three sugar beet varieties. A split block design with three replications was used. Main blokes were assigned to three irrigation water regimes (100%, 85%, and 70% of water requirement). The sub blot was occupied by three harvesting dates (180, 195 and 210 days). Sub- sub plots comprised three sugar beet varieties namely (RAVEL, SV1841and SA1686). Results indicated that reducing water supply reduced alpha - amino N present in the second season, Na present in the second season, and K present and sugar lost to molasses, but increased sucrose present, extractable present, QZ present, purity present, extractability present. Increasing harvesting date increased K present, sucrose present, extractable present, QZ present, purity present, extractability present but reduced alpha - amino N present, Na present and sugar lost to molasses in the second season. Sucrose present, extractable present, QZ present purity present and extractability present of RAVEL and SA1686 varieties were almost comparable but higher than those of SV1841 variety.

In this work, the possibility of cross-border activities between two regions in the framework of the investment contract is viewed as optimal allocation problems. The problems of determining the optimal proportion of funds to be invested in liquidity and technology are analyzed in two different environments. In the first case, we consider a two-region and two-technology economy in which both regions possess the same productive technology or project, but a different stream of return. While in the second case, we examine an economy where two regions (i.e., Indonesia and Malaysia) hold different Islamic productive projects with identical returns. Allocation models are formulated in terms of investors’ expected utility maximization problem under budget constraints with respect to regional and sectoral shocks. It is revealed that optimal parameters for liquidity ratio, technological investment profile, and bank repayment are analytically characterized by the return of a more productive project and the proportion of impatient and patient investors in the region. Even though both cases employ different assumptions, they provide the same expressions of optimal parameters. The model suggests that cross-border Islamic investment activities between two regions might be realized, provided both regions hold productive projects with an identical stream of return. This paper also shows that by increasing the lower return of the project approaching the higher return, a room for inter-region investment can be created. An analytical framework of an investment contract in terms of optimal allocation model is provided.

Analyzing a drug over its overlapped spectra utilizes sophisticated instruments and more toxic solvents, which has a deleterious effect on environmental safety. There is an alarming need to develop a simple, novel, and cost-effective method for determining combined substances that are non-toxic to the environment. So, the study aimed to develop four simple, fast and eco-friendly spectrophotometric techniques for quantifying clotrimazole and tinidazole in bulk and ointment dosage form. Stock solutions produced at concentrations of 7 to 13 and 17.5 to 32.5 µg/mL of clotrimazole and tinidazole in 10% v/v ethanol and scanned in the UV-visible range 200-450 nm, and used for all methods. The methods were validated according to the International Council for Harmonization guidelines and found to be within limits. Additionally, the outliers were tested by using the Grubbers test and found within limits. Finally, green evaluation studies show that the method is more environmentally friendly, as confirmed by four assessment tools.

This research aimed to study the approach of the community toward the decision to grow rice and economic crops, including appropriate resource allocation for use on a farm under a large plot agricultural system. The study areas were in Phan district, Chiang Rai province, Thailand, and the data were collected from a sampling of 400 field agriculturalists. The method used was to develop a mathematical model for growing crops with multi-objectives and in multi-periods, together with an agriculturist representative and experts in multiple-criteria decision-making (MCDM). This was to prioritize the importance of alternative crops and find the appropriate allocation of the resources to achieve the targeted goal. The results showed that agriculturists prioritized most toward the criteria for growing Japanese rice with a weight of 0.179 Kg., followed by transplanted rice, transplanted glutinous rice, garlic, sown paddy rice, and sown glutinous paddy rice, respectively. The study’s results also showed that the price fluctuation of the crop products resulted in more use of land and labor in order to increase the production to compensate for the low price, and this also resulted in the higher opportunity cost of growing transplanted rice. Therefore, growing transplanted rice during in season planting was considered the most effective way, while during the off season, either garlic or Japanese rice could be grown. A collective pattern for planning for using resources together in large plot agricultural areas, together with a clear marketing target would bring about effective use of the resources and reduce the risk in revenue from the fluctuation in prices and uncertainty of yields from drought. Moreover, technology development to solve the problem of the lack of labor would be deemed an important approach toward the enhancement of the competitiveness of agriculturists in the future as well.

The decision to purchase the best available electric power wheelchair (EPWC) for a person with a disability in a low-resource context is very stressful, whether it is based on financial circumstances or the availability of medical solutions. The study's objective is to assess the EPWC options available on the market, focused on a set of conflicting criteria. In this research, three multi-criteria decision-making (MCDM) approaches are used to make decisions. ENTROPY method for weightage calculation of various parameters, COPRAS and EDAS methods for evaluating and ranking alternatives are applied. Both COPRAS and EDAS are applied separately for ranking of selected wheelchair models, and to check the robustness of the applied method, sensitivity analysis on cost criterion is carried out. The result shows that for both methods, EPWC-1 is the top priority model to buy, whereas EPWC-7 is the worst model for COPRAS, and EPWC-10 is the worst model for EDAS among the ten alternatives.

In examining for unique insecticidal agents, two derivatives namely, 2-((3-cyano-4,6-distyrylpyridin-2-yl)thio)-N-(4-nitrophenyl)acetamide (2) and 3-amino-N-(4-nitrophenyl)-4,6-distyrylthieno[2,3-b]pyridine-2-carboxamide (3) were synthesized from distyrylpyridine-2-thione (1). The new compounds were structurally clarified by spectral and elemental analysis data. The insecticidal activity of these compounds were carried out against cowpea aphid, Aphis craccivora Koch. It is demonstrated that the compounds 2 and 3 have noteworthy insecticidal activity against nymphs of cowpea aphid with LC50 values of 0.025-0.027 ppm and 0.005-0.006 ppm after 24 h and 48 h of treatment, respectively. Also, the compounds 2 and 3 have noteworthy insecticidal activity against adults of cowpea aphid with LC50 values of 0.112-0.129 ppm and 0.014-0.015 ppm after 24 h and 48 h of treatment, respectively, that were comparable to that of the control acetamiprid.

Oxygen-containing heterocycles are largely distributed in natural and synthetic compounds. Coumarins are among the most famous heterocycles which possess one oxygen atom in their rings. Coumarins are classified as multifunctional scaffold and are used as anti-oxidant reagents, anti-inflammatory, anti-microbial, anti-fungal, anti-HIV active, analgesic, anti-histaminic, insecticides, dyes, herbicides, sensitizers, perfumes, cosmetics and food additives. Due to their diverse applications in industrial and pharmaceutical fields, many chemists have given significant interest to these compounds. Herein, the review highlights various methods for the synthesis and interactions of coumarin moiety as one of the most efficient categories of heterocycles.