Eco-friendly ultraviolet spectrophotometric methods for the determination of clotrimazole and tinidazole in bulk and ointment dosage form

Kannaiah, K.; Sugumaran, A.

Growing Science » Current Chemistry Letters » Eco-friendly ultraviolet spectrophotometric methods for the determination of clotrimazole and tinidazole in bulk and ointment dosage form

Journals

CCL Volumes

Volume 1 (23)
- Issue 1 (7)
- Issue 2 (5)
- Issue 3 (6)
- Issue 4 (5)

Volume 2 (26)
- Issue 1 (7)
- Issue 2 (6)
- Issue 3 (6)
- Issue 4 (7)

Volume 3 (30)
- Issue 1 (7)
- Issue 2 (10)
- Issue 3 (8)
- Issue 4 (5)

Volume 4 (21)
- Issue 1 (5)
- Issue 2 (5)
- Issue 3 (6)
- Issue 4 (5)

Volume 5 (20)
- Issue 1 (5)
- Issue 2 (5)
- Issue 3 (5)
- Issue 4 (5)

Volume 6 (20)
- Issue 1 (5)
- Issue 2 (5)
- Issue 3 (5)
- Issue 4 (5)

Volume 7 (15)
- Issue 1 (4)
- Issue 2 (4)
- Issue 3 (4)
- Issue 4 (3)

Volume 8 (20)
- Issue 1 (5)
- Issue 2 (5)
- Issue 3 (5)
- Issue 4 (5)

Volume 9 (20)
- Issue 1 (5)
- Issue 2 (5)
- Issue 3 (5)
- Issue 4 (5)

Volume 10 (43)
- Issue 1 (5)
- Issue 2 (7)
- Issue 3 (17)
- Issue 4 (14)

Volume 11 (43)
- Issue 1 (14)
- Issue 2 (11)
- Issue 3 (10)
- Issue 4 (8)

Volume 12 (78)
- Issue 1 (21)
- Issue 2 (22)
- Issue 3 (20)
- Issue 4 (15)

Volume 13 (68)
- Issue 1 (23)
- Issue 2 (17)
- Issue 3 (16)
- Issue 4 (12)

Volume 14 (20)
- Issue 1 (20)

Countries

Current Chemistry Letters

ISSN 1927-730x (Online) - ISSN 1927-7296 (Print) Quarterly Publication Volume 11 Issue 1 pp. 11-22 , 2022

Eco-friendly ultraviolet spectrophotometric methods for the determination of clotrimazole and tinidazole in bulk and ointment dosage form Pages 11-22 Download PDF

Authors: Kanaka Parvathi Kannaiah, Abimanyu Sugumaran

DOI: 10.5267/j.ccl.2021.11.001

Keywords: Clotrimazole, Tinidazole, Ethanol, Eco-friendly method, UV spectrophotometry

Abstract: Analyzing a drug over its overlapped spectra utilizes sophisticated instruments and more toxic solvents, which has a deleterious effect on environmental safety. There is an alarming need to develop a simple, novel, and cost-effective method for determining combined substances that are non-toxic to the environment. So, the study aimed to develop four simple, fast and eco-friendly spectrophotometric techniques for quantifying clotrimazole and tinidazole in bulk and ointment dosage form. Stock solutions produced at concentrations of 7 to 13 and 17.5 to 32.5 µg/mL of clotrimazole and tinidazole in 10% v/v ethanol and scanned in the UV-visible range 200-450 nm, and used for all methods. The methods were validated according to the International Council for Harmonization guidelines and found to be within limits. Additionally, the outliers were tested by using the Grubbers test and found within limits. Finally, green evaluation studies show that the method is more environmentally friendly, as confirmed by four assessment tools.

How to cite this paper

 Kannaiah, K & Sugumaran, A. (2022). Eco-friendly ultraviolet spectrophotometric methods for the determination of clotrimazole and tinidazole in bulk and ointment dosage form.Current Chemistry Letters, 11(1), 11-22.

Refrences

1. Moriarty B. Hay R. and Morris-Jones R. (2012) The diagnosis and management of tinea. BMJ., 345.
2. Speelman P. (1985) Single-dose tinidazole for the treatment of giardiasis. Antimicrob. Agents Chemother., 27 (2) 227–9.
3. Armstrong N. R. and Wilson J. D. (2010) Tinidazole in the treatment of bacterial vaginosis. Int. J. Womens. Health., 1 59–65.
4. Packard R. S. (1982) Tinidazole: a review of clinical experience in anaerobic infections. J. Antimicrob. Chemother., 10 (suppl_A) 65–78.
5. L,SINGH; S N. (2011) Method for Determination of Tinidazole using Direct UV-Visible Spectrophotometry and Differential Spectrophotometry in Pure and Tablet Dosage Forms. East Cent. African J. Pharm. Sci., 14 75–80.
6. Siddartha B. Sudheer Babu I. Parthiban C. and Prathyusha V. (2014) Method development and method validation of tinidazole in bulk and pharmaceutical dosage form by UV- spectrophotometric method. Res. J. Pharm. Technol., 7 (4) 467–9.
7. Mahmood S. Ahmad Z. Aslam M. Naeem F. Hussain A. and Kumar N. (2015) Method Development and Validation for the Estimation and Evaluation of Clotrimazole (an-Antifungal Drug) in Tablet Preparation by UV-VIS Spectroscopy. Int. J. Pharm. Sci. Rev. Res., 32 55–8.
8. Salo J. P. K. and Salomies H. (2003) Two stability-indicating UV spectrophotometric methods for the analysis of hydrolyzed tinidazole. J. Pharm. Biomed. Anal., 31 (3) 523–36.
9. Mayank P. Khemchand D. and Khatri N. C. (2012) Application of UV spectrophotometric methods for estimation of ciprofloxacin and tinidazole in combined tablet dosage form. Der Pharma Chem., 4 (SUPPL.3) 1041–6.
10. Mahmood S. Ahmad Z. Aslam M. Naeem F. Hussain A. and Kumar N. (2015) Method development and validation for the estimation and evaluation of clotrimazole (an-antifungal drug) in tablet preparation by UV-VIS spectroscopy. Int. J. Pharm. Sci. Rev. Res., 32 (2) 55–8.
11. Ismail N. B. S. and Narayana B. (2017) Spectrophotometric and spectroscopic studies on charge transfer complexes of the antifungal drug clotrimazole. J. Taibah Univ. Sci., 11 (5) 710–7.
12. velmuruganaƒ D. vairavel S. chandran R. . S. and nayak S. K. (2019) A Study Of Method Development, Validation and Forced Degradation Studies of Clotrimazole by Using UV Spectrophotometry. Am. J. PharmTech Res., 9 (2) 45–53.
13. Naguib I. A. Abdelaleem E. A. Hassan E. S. Ali N. W. and Gamal M. (2020) Partial least squares and linear support vector regression chemometric models for analysis of Norfloxacin and Tinidazole with Tinidazole impurity. Spectrochim. Acta - Part A Mol. Biomol. Spectrosc., 239 118513.
14. Priyanka C. P. Dr. Shailesh V. L. and Narkhede D. S. B. (2018) Analytical method development & validation for clindamycin, clotrimazole & tinidazole in pharmaceutical dosage form. Biomed. Eur. Pharm. Sci., 5 (5) 635–54.
15. Hemdan Abou-Taleb N. Mahmoud El-Enany N. Tawfik El-Sherbiny D. and Ibrahim El-Subbagh H. (2020) Digitally enhanced thin layer chromatography for simultaneous determination of norfloxacin and tinidazole with the aid of Taguchi orthogonal array and desirability function approach: Greenness assessment by analytical Eco-Scale. J. Sep. Sci., 43 (6) 1195–202.
16. Mali A. D. (2015) Estimation of domperidone in bulk and formulation by first order derivative area under curve UV-Spectrophotometry methods. Int. J. Pharm. Technol., 7 (1) 8040–8.
17. Chalikwar S. S. Shirkhedkar A. A. Bagul M. A. Jain P. S. and Surana S. J. (2012) Development and validation of zero and first-order derivative area under curve spectrophotometric methods for the determination of entacapone in bulk material and in tablets. Pharm. Methods., 3 (1) 14–7.
18. Korany M. A. Mahgoub H. Haggag R. S. Ragab M. A. A. and Elmallah O. A. (2017) Green chemistry: Analytical and chromatography. J. Liq. Chromatogr. Relat. Technol., 40 (16) 839–52.
19. Płotka-Wasylka J. (2018) A new tool for the evaluation of the analytical procedure: Green Analytical Procedure Index. Talanta., 181 204–9.
20. Tobiszewski M. (2016) Metrics for green analytical chemistry. Anal. Methods., 8 (15) 2993–9.
21. Kannaiah K. and Sugumaran A. (2021) ECO-FRIENDLY MULTIVARIANT GREEN ANALYTICAL TECHNIQUE FOR THE ESTIMATION OF KETOCONAZOLE BY UV SPECTROSCOPY IN BULK AND CREAM FORMULATION. Quim. Nova.,.
22. Pena-Pereira F. Wojnowski W. and Tobiszewski M. (2020) AGREE—Analytical GREEnness Metric Approach and Software. Anal. Chem., 92 (14) 10076–82.
23. Li Z. Smith K. H. and Stevens G. W. (2016) The use of environmentally sustainable bio-derived solvents in solvent extraction applications - A review. Chinese J. Chem. Eng., 24 (2) 215–20.
24. Henderson R. K. Jiménez-González C. Constable D. J. C. et al. (2011) Expanding GSK{’}s solvent selection guide – embedding sustainability into solvent selection starting at medicinal chemistry. Green Chem., 13 (4) 854–62.
25. US EPA. (2015) O. US EPA, defining hazardous waste: listed, characteristic and mixed radiological wastes, US EPA.
26. Kanaka Parvathi K. Sugumaran A. Hemanth Kumar C. and Seetharaman R. (2021) Environmental Impact of Greenness Assessment Tools in Liquid Chromatography – A Review. Microchem. J., 106685.