Composite marine structures are crucial for maritime and aerospace applications due to their strength-to-weight ratio and corrosion resistance. To ensure their reliability and durability, a methodology to predict the damage criticality and service life of composite marine T-joints is essential. Finite Element Analysis (FEA) has emerged as a powerful tool for preliminary design and structural evaluation of complex structures, reducing the need for extensive experimental work and leading to substantial cost savings. This research project aims to conduct a comprehensive FEA of composite T-joints, considering alternative skin, core, and infill materials. Structural analyses under various loading conditions will evaluate overall deflection and stress levels, aiming to enhance the design and reliability of composite marine constructions, ultimately improving their performance and extending their service life in demanding maritime and aerospace environments.

Bin packing problem (BPP) is a combinatorial optimization problem with a wide range of applications in fields such as financial budgeting, load balancing, project management, supply chain management. Harmony search algorithm (HSA) is widely used for various real-world and engineering problems due to its simplicity and efficient problem solving capability. Literature shows that basic HSA needs improvement in search capability as the performance of the algorithm degrades with increase in the problem complexity. This paper presents HSA with improved exploration and exploitation capability coupled with local iterative search based on random swap operator for solving BPP. The study uses the despotism based approach presented by Yadav et al. (2012) [Yadav P., Kumar R., Panda S.K., Chang, C. S. (2012). An intelligent tuned harmony search algorithm for optimisation. Information Sciences, 196, 47-72.] to divide Harmony memory (HM) into two categories which helps to maintain balance between exploration and exploitation. Secondly, local iterative search explores multiple neighborhoods by exponentially swapping components of solution vectors. A problem specific HM representation, HM re-initialization strategy and two adaptive PAR strategies are tested. The performance of proposed HSA is evaluated on 180 benchmark instances which consists of 100, 200 and 500 objects. Evaluation metrics such as best, mean, success rate, acceleration rate and improvement measures are used to compare HSA variations. The performance of the HSA with iterative local search outperforms other two variations of HSA.

Due to the advances in wireless network environments, consumers/end-user behaviors continue to expand in cyberspace. Similarly, university students (i.e. universities’ consumers) can easily shift from one university to another. In recent years, decision-makers in educational organizations have faced multi-criteria decision making (MCDM) problems in e-service adoption in order to improve quality standards and maintain students’ retention in highly competitive education environments. Generally, many required criteria in MCDM cannot be evaluated accurately since accurate data cannot be obtained from the decision makers’ assessments. Thus, this research aims to propose a decision-making model for identifying the factors that highly impact on e-service adoption in educational organizations. This new model combined the fuzzy Decision MAking Trial and Evaluation Laboratory (fuzzy DEMATEL) and fuzzy Techniques for Order of Preference by Similarity to Ideal Solution (fuzzy TOPSIS) to weight the interactions among the factors which were defined from a comprehensive review of literature and to determine the relative importance of these factors. The findings from our new proposed model: fuzzy DEMATEL-TOPSIS showed that environmental factors are the most important for effective e-service adoption among educational organizations in India. The proposed decision making model could guide educational organizations to improve their decisions related to technology adoption in their organizations. The conclusions and practical insights gleaned from this research could also hopefully be useful to school authorities in assisting with the adoption, acceptance, and usage of e-services.

A practical distribution system that arises in the context of delivering liquefied petroleum gas (LPG) through cylinders is considered in this study. To meet all the challenging constraints, the model is explicitly considered as a simultaneous pickup and delivery single commodity truncated vehicle routing problem with the homogeneous fleet of vehicles. The aim of this problem is to find the optimal routes for the set of vehicles locating at the distributing agency (DA), which offers simultaneous pickup and delivery operations over single commodity (i.e. LPG cylinders) to a fixed subset (need not serve all delivery centers) of delivery centers at rural level. The model is designed using zero-one integer linear programming. For proper treatment of the present model, an exact Lexi-search algorithm (LSA) has been developed. A comparative study is performed between the LSA and existing results for the relaxed version of the present model. Further, the efficiency of the LSA is tested through numerical experiments over small and medium CVRP benchmark test instances. The extensive computational results have shown that the LSA is productive and revealed that the real solutions have more consistent than the integral solutions in the presence of truncation constraint.

In the present work, synthesis of phthalimide and naphthalimide derived Biginelli compounds was performed. Allylation of phthalic & naphthalic anhydride, followed by ozonolysis resulted in the formation of N-phathalimido/naphpthalimido acetaldehyde (2 and 7). These aldehydes were subjected to Biginelli reaction using urea/thiourea and divergent β-keto esters in the presence of sulfated tin oxide (5 mol%) as catalyst in ethanol reflux to produce the corresponding dihydropyrimidinone compounds (5a-j and 8a-h). Additionally, both their antioxidant and anti-inflammatory functions were carried out. Compounds 5e, 5f, 5i, and 5j have shown potent to moderate potent activity for both antioxidant and anti-inflamamtory activities when compared to standard. Compounds 8c and 8g have shown potent antioxidant and anti-inflamamtory activities when compared to other compounds.

The current technique was developed to estimate the amount of alectinib present in spiked rabbit plasma using liquid chromatographic mass spectrometry. The liquid-liquid extraction method was used, and chromatographic separation was carried out on a C18 (4.6mm id x 50mm) analytical column with a mobile phase consisting of acetonitrile and water with 0.1% formic acid at a volume ratio of 75:25. Alectinib's product m/z +483.2 (parent) 396.1 (product) and the internal standard m/z +447.5 (parent) 380.3 (product) were both obtained using positive ion mode. The calibration curve was linear from 0.5 to 600 ng/ml. The percentage extraction recovery (98.15% → 98.86%), demonstrated excellent matrix and analyte selectivity (% interference = 0), and satisfactory stability study results in all types (% nominal 94.94% → 99.63%). The intra and interday accuracy with % nominal 97 → 98.8%, precision % CV ≤ 2% in all quality control levels. The rabbit model's pharmacokinetic parameters were examined, and alectinib's area under the curve (AUC 0—∞) was 4269 ± 8.13 hr.ng/ml. The half-life of elimination (t1/2) is 8.52 ± 6.66 hours. The currently established approach was used in rabbit blood samples for pharmacokinetic investigations of commercial formulations since it was thought to be a novel, verified bioanalytical method based on experimental results.

In the present work, we synthesized new thiosemicarbazone based Schiff base ligands and their Mn(II), Ni(II), Cu(II) and Zn(II) complexes. The synthesized compounds were characterized and their antimicrobial activities were studied. Elemental analysis, IR, ¹H-NMR and mass spectrometry were done to fully characterize all the compounds. The ligands and their complexes were screened for in-vitro biological study against Gram positive (Bacillus subtilis) and Gram negative (E. coli, Klebsiella pneumonia, Pseudomonas aeruginosa) bacteria for the Zone of Inhibition method. The thiosemicarbazone based complexes showed better activity than the ligands.

A potentiometric titration study has been undertaken to determine the cationic surfactant influence on mixed ligand complexes in ternary systems consisting of cobalt (II), nickel (II), copper (II), and zinc (II) with aspartic and citric acids at various concentrations (0.0–2.5% w/v) of the CTAB (Cetyltrimethyl ammonium bromide)-surfactant solution while maintaining an ionic strength of 0.16 mol L^-1 (NaCl) at 30 °C. Titrations were performed in the presence of different ratios (M:L:X = 1:2:2, 1:4:2, and 1:2:4) of metal (M) and aspartic acid (L) to citric acid (X) using sodium hydroxide. Model systems were developed based on statistical parameters and residual analysis. For Co(II), Ni(II), Cu(II), and Zn(II), the species detected were MLXH₂, MLX₂H₅, and MLX₃. The electrostatic relationship of the ligands' side chains, charge neutralization, chelate effect, stacking interactions, and hydrogen bonding are used to explain the trend in the variation of logarithm of stability constants (log β) values with changing dielectric constant and mole fraction of the surfactant. The variation in species distribution as a function of pH and surfactant composition is also presented and discussed, as are plausible equilibria for the formation of the species and structures of the ternary complexes are also presented and discussed.

The purpose of this article is to investigate the effect of various process parameters such as compaction pressure, sintering temperature, and time on the physio-mechanical properties of a powder metallurgy-fabricated composite made of pure aluminium/alumina. Temperatures (580°C, 600°C, and 630°C), periods (1.5, 2, and 2.5 hr), compacting loads (30KN-65KN), and alumina percentages (2, 4, 6, and 8weight percent) are all considered. X-ray diffraction (XRD) and X-ray fluorescence spectroscopy (XRF) studies are carried out to determine the phases present and their proportions. Crystallite size study is performed using XRD data, and the Al+4 weight % alumina composite has the smallest size of any composite tested. For optimization, sintering density, porosity, and microhardness are calculated. Scanning electron microscopy (SEM) is used to analyse the different microstructures. At 600°C, 2 hr of operating time, and 4weight% alumina additions, the highest sintering density and microhardness are found.

In this work, the multifunctional potential of four 3-acetylcoumarin derivatives was studied. The derivatives were significantly active against bacteria Staphylococcus aureus, Pseudomonas aeoginosa and fungal strain Candida albicans. The results of antioxidant activity assays were promising when compared to ascorbic acid. The in vitro anticancer activity was carried out using MTT assay on human cancer cell line COLO-205 and 3ACDT showed commendable antiproliferative activity along with appreciable tumor selectivity with distinct selectivity index. Moreover, ADMET properties of the compounds were determined using the pKCSM and SwissADME online tools and all compounds were found with good pharmacokinetic profile. Hence, from the obtained results from all the 3-acetylcoumarin derivatives, 3ACDT exhibited good therapeutical potential and can be optimized for lead development.