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Current Chemistry Letters

ISSN 1927-730x (Online) - ISSN 1927-7296 (Print)
Quarterly Publication
Volume 12 Issue 3 pp. 659-666 , 2023

In vitro antimicrobial activity of extracts from Kydia calycina and in-silico molecular docking studies of some phytochemicals Pages 659-666 Right click to download the paper Download PDF

Authors: Neha Dangi, Himanshu Mehendiratta, Shikha Sharma

DOI: 10.5267/j.ccl.2023.1.005

Keywords: Antimicrobial, Antifungal, Antibacterial, Molecular docking, Kydia calycina, In-silico studies

Abstract: Drug-resistant microorganisms are a serious problem, particularly when more strains become immune to different antimicrobials. Antibiotic resistance has now developed in several microbes. Therefore, it is crucial to build new medications that are still efficient. The amount of funding that is often available for such progress is lower than what is necessary. Kydia calycina is a Malvaceae flowering plant used in traditional Indian medicine to cure several diseases, including infections. The goal of this study was to determine whether K. Calycina has antifungal and antibacterial properties. Infections are caused by the profusion of microbes in the environment; thus, plant products and active chemicals are employed to assess the antimicrobial property of the extracts and the inhibition zone of each extract on a range of bacterial and fungal strains. The results showed that when it was applied to the species that were studied, there was a considerable decrease in the growth of bacteria. The plant was subjected to a phytochemical analysis, which was completed. This plant may be employed in the quest for bioactive natural substances that might be used as leads in the creation of pharmaceuticals. The antimicrobial mechanism of action was investigated by molecular docking, and it was determined that Hibiscoquinone B and Hibiscone C showed both antibacterial and antifungal activity.


How to cite this paper
Dangi, N., Mehendiratta, H & Sharma, S. (2023). In vitro antimicrobial activity of extracts from Kydia calycina and in-silico molecular docking studies of some phytochemicals.Current Chemistry Letters, 12(3), 659-666.

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Journal: Current Chemistry Letters | Year: 2023 | Volume: 12 | Issue: 3 | Views: 550 | Reviews: 0

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