Under solvent-free conditions, a simple and efficient procedure has been developed for the Michael addition reaction of active methylene compounds to β-nitrostyrenes. The resulting Michael adducts are efficiently converted into functionalized pyrazole derivatives with hydrazine hydrate in excellent yields. All the compounds were well characterized by spectroscopic techniques.

Fused heterocyclic derivatives have become an important scaffold nowadays, which could be used as a template in drug development and medicinal chemistry. Benzimidazole moiety is an imperious aromatic heterocycle which is frequently present in naturally occurring products such as purines, vitamin B 12 and histidine as well as synthesized bioactive compounds, indomethacin and albendazole, for example. This study comprises widespread and comprehensive literature analysis on chemical reactivity and biological properties associated with Benzimidazole containing molecules. Benzimidazole ring structure possesses an extensive variety of pharmacological activities in several medications of therapeutic interest against a variety of diseases such as hypertension, malaria, cancer, microbial diseases, inflammatory disorders, etc. Furthermore, this fused heterocycle benzimidazole core might interact with various anions and cations in addition to biomolecules over different reactions in the human body, therefore exhibiting wide-ranging biological activities such as antineoplastic, antibacterial and antifungal, anti-inflammatory and analgesic, antihypertensive, antiviral and antidepressant. In this review, we are focusing on the chemistry and recent biological activities, designing approaches, and SAR (structure-activity relationship) data of different benzimidazole-based analogues during the past years.

This study aims to measure people's decision-making to buy their pet insurance and compare it with the amount of insurance premium rates offered. It is important due to the increase in people's income which has triggered the birth of a community of pet lovers as part of the middle-class people’s lifestyle in Indonesia. The survey data was conducted using the Stated Preference (SP) format through questionnaires and interviews to determine the public response to pet insurance premiums. The collected data were analyzed using descriptive methods, decision-making analysis was on the basis of the choice of the dichotomous Contingent Valuation Method (CVM), and logistic regression analysis. Based on the calculation analysis using the logit method shows that the ability of the public to pay pet insurance premiums is IDR289,454.54. Analysis of calculations using the Turnbull method was obtained at IDR365,000.00. The results of the WTP amount, both using the logit method and using the Turnbull method, are greater than the minimum premium amount offered which is IDR190,000.00. The results of this study indicate that the premium rates for pet insurance offered are still within reasonable limits, compared to the size of the decision-making by the animal lover community in Indonesia. This provides a very good prospect for insurance companies that have insurance products for pets in Indonesia. This study was conducted to provide empirical evidence that the decision-making of the animal lover community is greater than the premium rate for pet insurance that has been offered. Thus, this research strongly supports the development of pet insurance companies in Indonesia, which can provide pet protection to stay healthy and well looked after.

In this article, the application of the Multi-Skilled Resource-Constrained Flow Shop Scheduling Problem (MSRC-FSSP) in preventive maintenance as a case study has been investigated. In other words, to complete each maintenance order at each stage, in addition to the machine, a set of required human resources with different skills must be available. According to human resources skills, each of them can perform at least one order or at most N orders, and each maintenance order must be done by a set of human resources with different skills. To carry out a maintenance order, different human resources must be in communication and cooperation so that a preventive maintenance order can be completed. In this article, these resources are considered as technical supervisors, repairmen and maintenance managers who complete all maintenance orders in a flow shop environment as a job. For this problem, a new Mixed Integer Linear Programming (MILP) model has been formulated with the two-objective functions, minimizing total orders completion time and the human resources idle time. To solve the model on a small scale, CPLEX is used, and to solve it on a large scale, due to the fact that this problem is NP-Hard, a meta-heuristic algorithm named Genetic Algorithm (GA) is presented. Finally, the computational results have been done to validate the model, along with the analysis of the human resources idle time.

Heavy metals contamination of water is a serious and complex environmental problem due to rapid industrialization, bioaccumulation and non-degradability. Therefore, the reuse of agricultural waste in the process of purifying water from pollutants is an attractive and promising method. Almost inexpensive materials are used to purify water, thus achieving the desired economic and environmental goal. In this study banana peel (BP) was used before and after modification by 0.1M sulphuric acid (H2SO4) to enhance the removal of Zinc Zn(II), Lead Pb(II) and Nickel Ni(II). The effect of various parameters was studied Such as pH, contact time, adsorbent dosage and initial metal ion concentration at 5 ppm. All these parameters were studied in batch experiments for a comparative study. The removal percentage was found to be 84% Zn (II),78%Pb (II) and 72% Ni (II) before modification and 92% Zn (II) , 94% Pb (II) and 96% Ni (II) after modification at initial concentration of 5 ppm. The data obtained from sorption isotherms were described with Langmuir and Freundlich isotherm models but were found to be well fitted for the Langmuir model. The correlation coefficient values R2 for Langmuir were at the range (0.996-0.999) while that for Freundlich were at the range (0.912-0.972). The rate of adsorption follows Pseudo-second-order kinetics. This work proved the high banana peels efficiency as an adsorbent agent for heavy metals removal from aqueous solutions.

The Internet of Things (IoT) has become essential for business. The adoption rate of IoT has dropped recently and this could be due to security, privacy, and trust issues. Blockchain (BC) has the potential to mitigate the risk of security, privacy, and trust. However, few studies examined the integration between IoT and BC in the context of developing countries. The purpose of this study is to examine the predictors of IoT adoption by telecommunication companies in the Gulf Cooperation Council (GCC). In addition, the study aims to examine the moderating role of BC as well as the effect of using IoT and BC on the competitive advantage of companies. Based on technology acceptance model, social exchange theory, and resource-based view, the study proposed that security, privacy, trust, communication quality, perceived ease of use (PEOU), and perceived usefulness (PU) affect positively the adoption of IoT. BC is proposed as a moderating variable and expected with IoT to affect the competitive advantage of companies. The population includes all the telecommunication companies in GCC. Data was collected using purposive sampling from IT professionals. The results of data analysis using SmartPLS showed that security, privacy, trust, PU, and PEOU positively affected the adoption of IoT. BC and IoT adoption have a positive effect on competitive advantage. Further, BC moderated only the effect of security and privacy on the adoption of IoT. Services providers must enhance the security, privacy, and trust of IoT services by deploying BC technology. Effective integration of IoT and BC will lead to the achievement of competitive advantages.

Metal complexes of [2-(2-hydroxynaphthalen-1-ylazo)-pyridin-3-ol] are derived from 2-amino-3-hydroxypyridine and β-naphthol was synthesized and characterized by thermal, spectral and analytical tools. The ligand was reacted with Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) in 1:2 stoichiometry. The IR spectra confirms the azo ligand coordination to metal ions via azo nitrogen and phenolic oxygen of pyridine after deprotonation. Both IR and 1HNMR spectra recorded involvement of deprotonated hydroxyl groups with proton displacement. The magnified fluorescence was shown by Mn(II) and Ni(II) complexes. None of the prepared ligands or complexes show any NLO activity with KDP as standard. The DNA cleavage and anticancerous activities done. The influence of zinc chelates on cure characteristics of rubber compounds was estimated based on rheometer measurements. The ligand and metal complexes are tested in vitro against some bacteria and fungi species. The antioxidant activities, DNA cleavage and anticancerous activities done. Ligand and its complexes catalysed cleavage of DNA.

A series of piperazine-based phthalimide derivatives 5 (a-l) were synthesized and extensively characterized using a variety of spectrum methods, including LC-MS, 1H-NMR, 13C-NMR, and FT-IR. All the derivatives were examined for their physicochemical, pharmacokinetic, bio-activity score, and PASS analysis. The 5e piperazine-based phthalimide derivative demonstrated promising antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) in the in vitro antibacterial studies. In comparison to streptomycin and bacitracin (10 µg/mL), the minimum inhibitory concentration of 5e against MRSA was discovered to be 45±0.15 micro g/ml. The anti-MRSA activity was validated with membrane damage studies by using SEM, and in silico docking studies were against 3VMT and 6FTB proteins of MRSA. In the toxicity study, 5e derivatives were evaluated against L6 cell lines. The results of the studies show the synthesized 2-(2-(4-((4-chlorophenyl) sulfonyl) piperazin-1-yl) ethyl) isoindoline-1,3-dione (5e) can be used for the development of anti-MRSA drugs.

In this paper, a memory-based simulated annealing algorithm called the Dual Memory Simulated Annealing Algorithm (DMSA) is presented to solve multi-line facility layout problems. The objective is to minimize the total material handling cost. Two memory buffers and a restart mechanism are considered. Two benchmark problems were selected from the literature review papers and solved using the standard simulated annealing (SA) algorithm and the DMSA. The obtained results show that solutions provided by the DMSA algorithm are cost-effective compared to the standard SA algorithm and the other algorithms used for solving these test cases. Moreover, to further evaluate the performance of the DMSA algorithm in large scale problems, eleven test cases were selected from the benchmark library of the quadratic assignment problem (QAP). According to the results, the performance of the algorithm in finding solutions to complex problems is exemplary.

The present paper elicits the zinc oxide nanoparticles-assisted synthesis of a new series of seven-membered 1,4-diazepine heterocyclic compounds as potent lead scaffolds. Structures of synthesized compounds were corroborated using spectroanalytical techniques viz, FT-IR, 1H, 13C NMR, Mass, and elemental analysis. Also, Field emission scanning electron microscopy (FE-SEM), Transmission electron microscopy (TEM), Energy dispersive x-ray analysis (EDAX), powder X-ray diffraction (PXRD), and Fourier transform infrared spectroscopy (FT-IR) were used to establish the structure and morphology of the synthesized nanocatalyst. The clean workup procedure, high to excellent yields, relatively short reaction times, and high atom economy are the incredible advantages associated with the protocol.