This paper considers the general lot sizing and scheduling problem (GLSP) in single level capacitated environments with sequence dependent item changeovers. The proposed model simultaneously determines the production sequence of multiple items with capacity-constrained dynamic demand and lot size to minimize overall costs. First, a mixed-integer programming (MIP) model for the GLSP is developed in order to solve smaller size problems. Afterwards, a matheuristic algorithm that integrates Simulated Annealing (SA) algorithm and the proposed MIP model is devised for solving larger size problems. The proposed matheuristic approach decomposes the GLSP into sub-problems. The proposed SA algorithm plays the controller role. It guides the search process by determining values for some of the decision variables and calls the MIP model to identify the optimal values for the remaining decision variables at each iteration. Extensive numerical experiments on randomly generated test instances are performed in order to evaluate the performance of the proposed matheuristic method. It is observed that the proposed matheuristic based solution method outperforms the MIP and SA, if they are used alone for solving the present GLSP.

By the reaction of substituted benzaldehydes and indol-3-carbaldehydes (2E)-2-cyano-N-[5-(R-benzyl)-1,3-thiazol-2-yl]-3-(R1-phenyl)prop-2-enamides 3-(1-R¹-1H-indol-3-yl)-2-cyano-N-(5-(R-benzyl)-1,3-thiazol-2-yl)prop-2-enamides were synthesised. The antitumor activity of prepared compounds were investigated. 3-(1-Benzyl-¹H-indol-3-yl)-2-cyano-N-(5-(2-chlorobenzyl)-1,3-thiazol-2-yl)prop-2-enamide (7b) has been identified as hit compound with values of MG-MID GI50 = 3.903 µM, TGI = 29.10 µM, LC50 = 57.54 µM.

This study examines the influence of mental accounting, financial attitudes, financial knowledge, and financial self-efficacy on the financial behavior of diligent students in using fintech. This study differs from previous research because it uses a sample of students who already have a business and often use fintech. Data collection was carried out through the distribution of questionnaires to respondents. This study found that financial attitudes and self-efficacy had a significant effect on financial behavior, while financial knowledge had no significant effect on financial self-efficacy and mental accounting. Mental accounting significantly affects financial attitudes, financial behavior, and financial self-efficacy. These findings prove the importance of mental accounting in increasing the confidence and effectiveness of students who often use fintech and have a business in making financial decisions. This research contributes to developing the theory of planned behavior in the context of financial behavior. It reveals that financial literacy does not necessarily increase financial self-efficacy and mental accounting, especially among students who often use fintech and are just starting a business.

PEG-400 has been found to be an efficient recyclable catalyst/solvent system for C3- and O-alkylation of 4-hydroxycoumarin with various electronically and structurally divergent alcohols with moderate to good yield of products. For the C3-alkylation using styrenes required Zn(OAc)2.2H2O (5 mol%) in PEG-400 at 70 °C. For the O-alkylation of 4-hydroxycoumarin with acetates required PEG-400 at 60 °C. This process offered a gentle and uncomplicated way to obtain multi-substituted pyranocoumarins, as well. This protocol's benefits include its wide use, moderate environment, low cost, reusable catalyst (PEG-400), and ease of usage due to the only byproducts being acetic acid and water, respectively.

In order to promote green and sustainable development of the transportation industry, an increasing number of logistics companies have begun to deploy electric vehicles (EVs) to provide urban distribution services. This paper studies a Half-Open Time-Dependent Multi-Depot Electric Vehicle Routing Problem Considering Battery Recharging and Swapping (HOTDMDEVRPBRS) in last-mile delivery. Based on the calculation functions of EV energy consumption, travel time, and carbon emissions under the time-dependent road network, a mixed integer programming model is formulated. The goal of the model is to minimize the economic cost and environmental cost of logistics companies. Given the complexity of the problem, this paper designs a multi-objective simulated annealing algorithm (SAA). Finally, this paper carries out comprehensive computational experiments to verify and evaluate the performance of the proposed model and method and examines the economic and environmental benefits brought by the Half-Open Joint Distribution Mode (HOJDM). According to the results, SAA shows good performance and provides a high-quality solution. Meanwhile, the HOJDM significantly reduces the total cost and carbon emissions of logistics enterprises and provides valuable suggestions for enterprise managers and government decision-makers.

The agriculture sector and other agribusinessescan have a long-lasting effect on the environment. The present studyinvestigates the effect of Agricultural Supply Chain Management (ASCM), fromproducer to consumer, on Environmental Sustainability (ES) in the Alkharj governorateby collecting primary data from 312 respondents in the ASCM in Alkharj and byapplying Structural Equation Modelling (SEM). Moreover, the moderating roles ofeconomic and social sustainability in the nexus between ASCM and the ES arealso tested. The results of the analyses show that ASCM directly improves theES in the agriculture sector. Moreover, ASCM also improves both economic andsocial sustainability. Consequently, economic and social sustainability improvesthe ES. Thus, economic and social sustainability have positively moderated therelationship between ASCM and the ES. The results suggest that the governmentof Alkharj governorate should further improve the economic sustainability ofagribusinesses in Alkharj by providing incentives. Moreover, education andtraining programs should be initiated to improve social sustainability. Thus,both improved social and economic sustainability of agribusinesses could encouragesustainable practices to promote the ES in the whole ASCM in Alkharj.

Pyrazoles are highly versatile and find applications in various industries including chemicals, pharmaceuticals, polymers, medications, and agriculture. Pyrazoles and their analogues exhibit a range of biological activities, including anti-inflammatory, anti-tuberculosis, antibacterial, antifungal, anti-cancer, and anti-diabetic effects. In this context, this investigation focuses on the synthesis of pyrazoles containing heterocyclic components using Amberlite resin in reactions with ultrasonic irradiation. Synthesized pyrazoles containing heterocyclic components are intermediates of the apixaban API. Some pyrazole derivatives are key impurities of the apixaban API, which is synthesized by a multistep chemical conversion and has been reported previously. The use of the heterogeneous Amberlyst resin, which acts as a reusable catalyst and is gentle on reactions, allows for a more sustainable solution that reduces costs, accelerates reactions, and shortens reaction times. The procedures for using Amberlyst resin under ultrasonic irradiation to synthesize pyrazole derivatives are cost-effective, energy-efficient, and environmentally friendly for chemical synthesis and material preparation. They also simplify workups and produce quality and yields comparable to or better than existing methods.

The purpose of this study is to investigate the direct effects of environmental sustainability orientation (ESO) on green supply chain management (GSCM), ESO on sustainable performance (SP), and GSCM on sustainable performance (SP). It also examines the indirect effect of GSCM on SP through the mediating role of GSCM. Moreover, it tests the moderating role of environmental collaboration (EC) between GSCM and SP. A total of 155 survey questionnaires were collected from firms with ISO 14000 certification in the manufacturing sector in Algeria. The gathered data was examined using (PLS-SEM) model. The findings showed positive effects between ESO, GSCM, and SP. However, no such effect was detected for the moderating role of environmental collaboration on the links between GSCM and SP. The limitation of this study was the use of only firms with ISO 14000 certification, so future studies should consider a wider range of firms and different scales. Regarding environmental problems, firms in Algeria can apply ESO and GSCM to achieve sustainable performance.

This study examines the collective impact of postponement, scrap, and subcontracting standard components on the multiproduct replenishing decisions. Rapid response, desirable quality, and various goods guide the client’s demands in today’s competitive market. Therefore, many manufacturing firms search for alternative fabrication and outsourcing strategies during the production planning stage to satisfy the client’s expectations, minimize fabrication-inventory costs, and smoothen machine utilization. To effectively help producers meet today's client's needs and enhance their competitive advantage, we develop a two-stage multiproduct replenishing system incorporating scraps, standard parts subcontracting, commonality, and delayed differentiation. To reduce the production uptime, stage one has a hybrid fabrication process for the common components (i.e., a partial outsourcing strategy), and stage two manufactures the finished multiproduct. In-house fabrication processes in both stages are imperfect; a screening process detects and removes scraps to maintain the finished batch quality. We determine the cost-minimized operating cycle. The findings reveal the collective impact of postponement, scrap, and external suppliers on this multi-product replenishment problem and can be used to facilitate production planning and decision-making.

Nitrones are an interesting group of organic compounds due to their spin-trapping properties. These chemical compounds are also useful building blocks via cycloaddition reactions. In this work, a comprehensive study about correlation of selected parameters come from quantum chemical and experimental studies, namely 1H chemical shifts, IR absorption bands and UV-Vis maximum absorptions as well as reactivity descriptors such as global electrophilicity and nucleophilicity with substituent constants of Hammett, Taft, Brown and Okamoto's as well as Exner for para substituent analogues of (Z)-C-phenyl-N-methylnitrones have been study. Based on presented results it should be noted that tested models of substituent constants correlate in a satisfactory way with computational data. The opposite conclusion is observed for spectral data derived from analysis performed for synthesized nitrones. The obtained results constitute a useful element for future research on reaction mechanisms involving the tested nitrones.