Several Plant products have been found to be a part of phytomedicines since time immemorial. These plant products can be derived from barks, leaves, flowers, roots, fruits, and seeds. It has been found that the light radiation affects the antimicrobial activity of herbal products. The present study was aimed to investigate the phytochemical screening and antimicrobial activities of Calotropis gigantea leaf extracts. In addition to these studies we also check the effect of UV light radiation on the anti microbial activity of leaf extract. Phytochemical screening revealed the presence of various active phytochemicals in the extracts of aerial part of Calotropis gigantea. Ethanol, chloroform and hexane extract of leaves were tested against Clostridium botulinum, Proteus vulgaris, Escherichia coli and Arthrographis cuboid, Aspergillus fumigatus, Aspergillus niger by the agar disc diffusion method. The antimicrobial activity of the extracts generally reduces significantly after exposure to the UV radiations.

Research on the profile of Fe in the seagrass ecosystem has been carried out. Analysis of seawater, sediment, seagrass samples from the association of mangroves, mangroves-coral reefs and coral reefs taken in the waters of Donggala Regency was carried out using the ICP-OES method (Inductively Coupled Plasma-Opticaly Emission Spectrometry). It turns out that seagrasses associated with mangroves have higher iron concentration in their ecosystem, both in waters, sediments, and in seagrass plants and will be lower in association with mangroves and their association with coral reefs. Likewise, the status of seagrass has a higher concentration of Fe than infertile status or poor status. The results become some reference to show that seagrass plants can be bio-indicators of marine waters fertility.

In this study, the selective oximation of structurally diverse aromatic aldehydes (versus ketones) to the corresponding aldoxime derivatives was investigated using the combination system of NH₂OH.HCl and bisthiourea complexes of cobalt, nickel, copper and zinc chlorides, M^II(tu)₂Cl₂, in a mixture of CH₃CN‒H₂O (1:1 mL). All reactions were carried out successfully at room temperature within the immediate time up to 130 min giving the products in high yields. Investigation of the results exhibited that the applied bis-thiourea metal complexes show the catalytic activity in order of Co(tu)₂Cl₂₂Cl₂₂Cl₂₂Cl₂ in their oximation reactions.

The interaction of (2-aryl-5-(hydroxyalkylamino)-1,3-oxazol-4-yl)phosphonates with hydrogen chloride, hydrogen iodide and hydrogen thiocyanate in anhydrous medium led to formation of new phosphorylated peptidomimetics containing C-terminal ω-haloalkyl and ω-thiocyanoethyl residues.

A novel trimetallic W-Mg-Al oxide composites immobilised onto starch were synthesized via sol-gel method. W-Mg-Al oxide composites were synthesized by first preparing WO₃ using incipient wetness method, followed by immobilising onto MgO-Al₂O₃ support using starch as binder. The effects of starch addition on the crystal properties and morphology were investigated by X-ray diffraction (XRD), Fourier Transform Infrared (FT-IR) spectroscopy and Scanning Electron Microscopy (SEM). In the presence of hydrogen peroxide and acetic acid as oxidant system, W-Mg-Al oxide starch composites exhibited higher catalytic performances for oxidative desulphurisation (ODS) of dibenzothiophene (DBT) at 95% compared to W-Mg-Al oxide composites. The catalytic activity observed could be correlated to the distribution of active phases on starch as well as the higher crystallinity of the metal oxide composites.

Synthesis of 1, 2-disubstituted benzimidazoles by reaction of N-substituted benzene-1,2-diamine with different aldehydes was developed. This greener procedure proceeds with the help of oxygen in water at 60oC. The advantages of proposed method are catalyst-free conditions in water, short reaction time and excellent yields.

In this study, a green and practical approach towards Hantzsch dihydropyridine synthesis of acridine-1,8-diones is introduced. Via the mentioned protocol, the one-pot condensation reaction of structurally diverse aromatic aldehydes, dimedone and NH4OAc was promoted by microwave radiation at solvent and catalyst-free conditions. Consequently, acridinedione products were produced in 81‒97% yields within 3‒8 min. The current protocol represents the prominent advantages in terms of the using a simple synthetic procedure, short reaction times, mild reaction conditions, high yield of the products as well as omission of hazardous and cost-effective organic solvents/reagents.

Seafood processing operations generate a high strength wastewater, which contain organic pollutants in soluble, colloidal, particulate form and salt content, up to 30g NaCl/L. This research aimed to study the effect of salt (NaCl) concentration on the treatment efficiency of seafood processing wastewater by the use of a laboratory-scale bioreactor, which is operated in anaerobic combining aerobic system with concentration salt different from 0- 5%. The results showed that the wastewater from seafood processing with the chemical input parameters of pH = 7 - 8.5, COD = 2000 mg / L, total nitrate nitrogen = 150 mg / L, NH⁴⁺ = 90 mg / L, total phosphorus = 50 mg / L, salt content 3% was treated with anaerobic activated sludge content of 8000mg/l, 16HRT and combining an aerobic activated sludge content of 6000mg/l, 6HRT, DO=2-4mgO₂/l with the acclimatization of 7% bacteria Bacillus velezensis at high salinity The parameters output wastewater was treated according to standards QCVN 11-MT:2015/BTNMT (column B).

Five imidazo[1,2-c]pyrimidine and pyrimido[1,6-a]pyrimidine derivatives were designed, synthesized and evaluated for their antiproliferative activity and cytotoxicity. Primary bioassays in vitro showed that two of five synthesized compounds, 6-benzyl-8-(methylsulfonyl)-2,6-dihydroimidazo[1,2-c]pyrimidin-5(3H)-one, and 9-(methylsulfonyl)-7-propyl-2,3,4,7-tetrahydro-6H-pyrimido[1,6-a]pyrimidin-6-one possessed potent antiviral activity against BKV (EC50: 0.66 μM and 0.96, respectively). The selectivity index of these compounds is similar to that of cidofovir. Although antiviral activity was evident in secondary assays, significant virus inhibition occurred at or near the cytotoxic concentration (SI90=1). Here we show that substituted pyrimidine derivatives are a promising structure class of chemical compounds for the development of antiviral drugs against BKV infections. Hence these compounds may be taken as lead compounds for further development of novel antimicrobial and anticancer agents.

[Leu]⁶-aureobasidin K 1 is an analog of AbK, in which aIle residue at the sixth position of AbK is replaced by Leu. [Leu]⁶-AbK 1 was successfully synthesized using a combination of solid- and solution-phase that has a difference with the previous method applied for the synthesis of other aureobasidin analogues, [2S,3S-Hmp]-AbL 2. The linear precursor was prepared by using solid-phase method with Fmoc strategy, in which an ester bond was constructed on the resin. The cyclic product was obtained from a solution-phase reaction of the linear precursor using HATU reagent. The crude of the cyclic peptide was purified using a column chromatography technique to obtain [Leu]⁶-AbK 1 with a percent yield of 5.31% that is higher compared to previous similar method for synthesis of [2S,3S-Hmp]-AbL 2. The purity level of cyclic product was analyzed using analytical RP-HPLC (t_R = 6.49 min) and analysis of structure using ¹H-NMR.