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Current Chemistry Letters

ISSN 1927-730x (Online) - ISSN 1927-7296 (Print)
Quarterly Publication
Volume 13 Issue 3 pp. 477-482 , 2024

Design, synthesis and characterization of new azoflavone derivatives through diazotisation - coupling reactions of aromatic amines (sulfanilic acid, 2-amino pyridine) Pages 477-482 Right click to download the paper Download PDF

Authors: Hadi Aqel Khdera

DOI: 10.5267/j.ccl.2024.3.002

Keywords: Azochalcone, Azoflavone, Diazotisation-coupling reaction, Cyclization, Aldol condensation

Abstract: In this research, new azochalcone derivatives (6, 7) were synthesized by using three methods: the first one is diazotization - coupling method of different aromatic amines (sulfanilic acid, 2-aminopyridine) with chalcone (5), the second, aldol condensation method of azoaryl hydroxyacetophenone compounds with 4-dimethylamino benzaldehyde in presence of sodium hydroxide as a catalyst, the last one is method of aldol condensation of azoaryl hydroxyacetophenone compounds with 4-dimethylaminobenzaldehyde in presence of piperidine as an organic catalyst. The yield was the best by using the aldol condensation method with sodium hydroxide as a catalyst. New azoflavone derivatives (8, 9) with good yields (78-84 %) were also synthesized by performing cyclization reactions of azochalcone derivatives using iodine in dimethyl sulfoxide. The identity of the new compounds was determined using spectroscopic methods (FT-IR, 13C-NMR, 1H-NMR).

How to cite this paper
Khdera, H. (2024). Design, synthesis and characterization of new azoflavone derivatives through diazotisation - coupling reactions of aromatic amines (sulfanilic acid, 2-amino pyridine).Current Chemistry Letters, 13(3), 477-482.

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Journal: Current Chemistry Letters | Year: 2024 | Volume: 13 | Issue: 3 | Views: 319 | Reviews: 0

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