Ultrasound-assisted synthesis and biological significance of substituted 4H-chromene-3-carbonitrile using greenery approaches

Chavan, P.; Pansare, D.; Shelke, R.; Shejul, S.; Bhoir, P.

Growing Science » Current Chemistry Letters » Ultrasound-assisted synthesis and biological significance of substituted 4H-chromene-3-carbonitrile using greenery approaches

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Current Chemistry Letters

ISSN 1927-730x (Online) - ISSN 1927-7296 (Print) Quarterly Publication Volume 10 Issue 1 pp. 43-52 , 2021

Ultrasound-assisted synthesis and biological significance of substituted 4H-chromene-3-carbonitrile using greenery approaches Pages 43-52 Download PDF

Authors: Pravin Chavan, Dattatraya Pansare, Rohini Shelke, Sumit Shejul, Pratima Bhoir

DOI: 10.5267/j.ccl.2020.7.003

Keywords: MCRs, 4H-chromene-3-carbonitrile, Orange juice, Reflux, Ultrasonication

Abstract: A synthesis of 2-amino-4-(R)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile derivatives (4a-l) in single flasks containing aromatic aldehydes (1a-l), malononitrile (2), and dimedone (3) by using green catalyst, extract of orange without solvent under ultrasound irradiations and reflux condition. Synthesis of 2-amino-4-(R)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile derivatives (4a-l) show potent in-vitro anti-inflammatory activity. All synthesized compounds were characterized by FTIR, ¹H NMR, ¹³C NMR and mass spectroscopic data & elemental analysis.

How to cite this paper

 Chavan, P., Pansare, D., Shelke, R., Shejul, S & Bhoir, P. (2021). Ultrasound-assisted synthesis and biological significance of substituted 4H-chromene-3-carbonitrile using greenery approaches.Current Chemistry Letters, 10(1), 43-52.

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