A convenient and efficient synthesis of a series of ethyl-1-(6-(4-substitutedacetylatedpiperazin-1-yl)pyrimidin-4-yl)-5-amino-1H-pyrazole-4-carboxylate (8a-8j) has been developed by five steps which include activation of a methylene group, hydrazinolysis, cyclisation and chloro-amine coupling reactions. Moreover, our proposed mechanism was confirmed in this study demonstrating that ethyl 5-amino-1-(6-chloropyrimidin-4-yl)-1H-pyrazole-4-carboxylate is the key intermediate to fulfill the desired outcomes. In silico and in vitro studies were carried out to identify the active agents among the developed adducts against mycobacterium tuberculosis (PDB ID:4TRO). Compound 8a (Docking Score: -26.81 and MIC: 1.6 ug/mL) was found to be the most potent among the synthesized molecules. All the synthesized compounds showed acceptable drug-like properties which make them suitable for further lead modification using in silico design approaches.

Under solvent free conditions and in presence of a base 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives were synthesized by grinding technique. Structural investigations were carried out with IR studies, HRMS, ¹HNMR and ¹³CNMR. The compounds were checked for their in vitro anticancer activities against three different human cancer cell lines viz human breast cancer cell line (MCF-7), human cervical cancer cell line (HeLa) and human oral squamous cell carcinoma (SCC-40) using SRB method. All the title compounds showed low toxicity towards non-malignant PBMC cells indicating their tumour selectivity. The compounds exhibited good in vitro anti-proliferative potency at lower concentrations against HeLa and MCF-7 cell lines and remain moderately active against SCC-40.

Microbes generally develop resistance towards organic antibacterial agents like ampicillin, Sulfonamides, methicillin, etc., and progressively new drugs are being invented to replace them. Hence, replacement of organic antibacterial agents with inorganic analogues requires constant research and the present investigation reports alternatives for conventional antimicrobial agents like methylparaben, diazolidinyl urea, etc., in the cosmetic products with silver incorporated calcium borates. The chemically synthesized silver-calcium borates have been analyzed for phase purity using powder XRD analysis, nature of bonding using FTIR vibrations, and morphology using SEM. The antibacterial and antifungal studies were carried out for the novel inorganic silver-calcium borates incorporated cosmetic products. The products were also subjected to thermal & photostability studies and found to be comparable with that of commercially available products. A minimum quantity of 3 ppm of silver-calcium borate concentration was required to bring about nearly 100% bacterial reduction in the cosmetic products.

Pyrimidine compounds continue to attract great interest in the field of organic synthesis due to their various chemical and biological applications observed, especially in recent times. As a result, this review covering some periods from 1957 to 2021 has been prepared to discuss some of the structural pathways of these compounds as well as some of their interactions and applications.

A new series of 2-[3-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-1-phenyl-1H-4-pyrazolyl]-3-aryl-1,3-thiazolan-4-one 5(a-i) have been designed, synthesized and evaluated for their in vitro antibacterial activity against Gram positive bacteria viz. Bacillus subtilis (ATCC 6633), Staphylococcus aureus (ATCC 6538p), Micrococcus luteus (IFC 12708) and Gram negative bacteria viz. Proteus vulgaris (ATCC 3851), Salmonella typhimurium (ATCC 14028), Escherichia coli (ATCC 25922) the antifungal activity against Candida albicans (ATCC 10231), Aspergillus fumigatus (HIC 6094), Trichophyton rubrum (IFO 9185), Trichophyton mentagrophytes (IFO 40996). Antibacterial evaluation indicates that compounds containing 4-methoxyphenyl 5c, 4-fluorophenyl 5d and 2,5-difluorophenyl 5h groups on thiazolidinone ring showed significant activity equal to that of standard drug. The antifungal evaluation shows that compound 5c is highly active against A. fumigatus, compound 5d and 5h were also active against C. albicans and A. fumigatus.

Solution for a normally loaded infinite isotropic plate containing five cracks with coalesced yield zones is obtained using a complex variable method. Influence of coalesced yield zones on the load bearing capability of the infinite plate is analyzed. Analytical expressions for stress intensity factors, displacement components and crack opening displacement (COD) are obtained. Numerical study is carried out to determine the yield zone length, applied load ratio and COD. The numerical results are reported graphically between some important parameters.

The present work aims to investigate the effect of an edge crack on the stress concentration around the circular hole surrounded by Functionally Graded Material (FGM) in an infinite plate subjected to uniaxial tensile load. The numerical investigation has been carried out using Extended Finite Element Method (XFEM). Two cases have been analysed in this work, i.e. the whole plate made up of radial FGM and homogeneous material plate having radial FGM layer around the hole. Young’s modulus of FGM varies according to exponential and power law function. The relations of stress intensity factor (SIF) and stress concentration factor (SCF) with normalised crack length, Young’s modulus ratio, FGM layer thickness and power law index have been presented. It has been observed that the FGM layer case has low SCF around hole than FGM plate case in presence of an edge crack.

The number of types of wire welding that circulate on the market and the development of welding technology, especially related to current welding, create a lack of information related to the quality of welding results for several types of materials. This can cause the strength of the welding connection to not be maximized. Therefore, this study aims to optimize the use of three types of wire welding and three current welding on the strength of the welding connection in two types of material testing using the response surface methodology. Box-Behnken, coupled with the RSM and the desirability function, was used to optimize the strength of the welding connection of the wire types (RD-46, LB-52, and RB-26), and current welding (100, 130, and 160 A) against two types of material testing (IWF-150 and ASTM-A517-G70). The strength of the welding connection observed in response included the tensile strength, Charpy impact-absorbed energy, hardness values in the welding metal and the hardness values in the main metal. Optimization of the strength of the welding connection in this study recommends the application of wire types RB-26, current welding of 100 A, and ASTM-A517-G70 material testing with the highest desirability value of 71.6%. Optimization of tensile strength, Charpy impact-absorbed energy, hardness values in welding metal, and hardness values in main metal by applying this parameter are 575.64 MPa, 110.69 J, 216.75 (HV10) and 126.6 (HV10), respectively. The results proved that an appropriate welding connection strength could be achieved using wire welding types and current welding in material testing.

In this article, hyperelastic material models that state consistent polynomial expansions of the stored energy function are discussed. The approach follows from the multiplicative decomposition of the deformation gradient. Some advantages of the third-order expansion model over the five-parameter Rivlin model using Treloar’s experimental data are shown. The models are qualitatively and quantitatively compared to highlight these advantages of the discussed model.

This study presents data on the development and research of cryogenic-vibration grinding process modes which would ensure an efficient grinding process of complex composite systems with a high degree of heterogeneity of components in their composition of products such as fluoroplast, bismuth oxide and tungsten carbide. The general regularities of low-temperature processing and grinding of non-degassed elastomers are established. A method has been tested that establishes the regularities of cryogenic grinding and ultrasonic homogenization of a complex mechanical system, the microstructure and dispersed compositions of the ground material have been determined.