In this paper, an innovative and efficient sandwich panel is proposed for the structural walls for quickly assembled post-disaster housing, as well as load bearing panels for pre-fabricated modular construction and semi-permanent buildings. This study focuses on the flexural and shear behavior of the innovative sandwich panels, which is composed of two 3-D high density polyethylene (HDPE) skins, and high-density Polyurethane (PU) foam core. An experimental study was carried out to validate the effectiveness of this panel for increasing the ultimate bending strength. A series of experimental tests were performed on medium-scale specimens to characterize their core shear behavior. Then, some supplementary tests were run to determine the panels’ flexural and shear stiffness. The numerical and experimental investigations show that the 3-D-HDPE sheets, manufactured with a studded surface; considerably enhance the pull-out and delamination strength. Good agreement has been observed between the numerical and experimental tests.