The purpose of this study is to investigate the mediating role of operational flexibility between the quality of health information technology and management capability. A cross-sectional study was conducted; data was obtained based on 365 medical staff (medical doctors, nurses, and medical technologists) from public hospitals in the northern region of Jordan; a covenant sample was used. The authors used structural equation modeling to verify the hypotheses. The results reveal that the quality of health information technology has a significant impact on management capability and operational flexibility. Operational flexibility as a partial mediating variable also showed a significant impact on management capability. The study suggests that increasing the quality of health information technology will enhance the management capability and operational flexibility in healthcare organizations and will increase employee loyalty as a vehicle to trigger positive work-related attitudes. This study is one of the very limited studies in the Middle East that examined the role of operational flexibility in the quality of health information technology and employee management capability.