In this work, ribonucleoside products have been prepared by employing stannic tetrachloride (SnCl4) and natural phosphate as catalysts. The obtained result suggests that this catalyst facilitates the reactions of ribonucleoside-like products in a stereo-controlled manner, exhibiting β-selectivity when reacting with trimethylsilyl uracil, the ribonucleosides derivatives were obtained in suitable yields. In addition, we have performed the molecular docking analysis, demonstrated that the synthesized compounds have potential for antiviral activity against the omicron variant of coronavirus, and the D3, D4, E and F products have a higher binding energy than the molnupiravir drug, indicating that these products may be a probable drugs for the omicron variant.

This study proposes a new scenario planning approach which consists of two main stages: evaluating scenarios under multiple criteria and selecting a manageable number of representative scenarios covering a wide range of future developments. In the evaluation stage, the interaction between criteria has been considered, which offers a significant contribution both to the scenario literature and practice. In the selection stage, a mathematical programming model has been developed to ensure the selection of distinct scenarios with high evaluation values. The approach is applied to an urban mobility system in a metropolitan area. The selected scenarios provide valuable insights into the future of urban mobility, serving as a basis for identifying strategies. The proposed approach does not offer a solution only for scenario planning problems, it can be effectively applied to similar problems in different areas.

In the new stage of promoting high-quality economic development, the effect of the transformation of development momentum and the ability of sustainable development has become the key factors for the competitiveness of provinces in China. Especially in the context of the impact of COVID-19 and the obstacles of world trade protectionism, the sustainability of development performance is increasingly important. In the past, when evaluating the development performance of various provinces in China, a single index weight was usually used. In view of evaluation criteria, the lack of consideration of regional differentiation factors would result in the evaluation results deviating from reality. This paper introduces the entropy weight method to determine the weight of regional indicators of differentiated development. Based on the space-time probability function, a grey clustering evaluation model of regional development performance is constructed to conduct a comprehensive grey evaluation of the development performance of various provinces in China from 2009 to 2019. It is found that the new evaluation model can correct the deficiencies of similar probability functions and single index weight and obtain more accurate evaluation results. It’s found that the development performance evaluation results of each province are always in a dynamic adjustment process, which needs to be verified with the help of subsequent expansion analysis.

This paper proposes a matheuristic approach for the location-routing of industrial platforms of the pineapple supply chain problem. We have proposed a three-phase methodology to solve the considered problem. The first phase consists of obtaining the potential supply in terms of suitability and productivity, the potential location of platforms, and the times of the value chain echelons. In the second phase, a mathematical optimization model for the location problem of platforms considering the coverage in terms of timing is proposed. Finally, the final phase proposes a cluster-routing and a granular reactive tabu search approach for the routing phase. The proposed methodology uses official information on production times, speed, and capacity and georeferenced aptitude, spatial, economic, and land yield information for the first time. The proposed approach has been validated through scenarios, particularly pineapple exports for the Colombian country. The obtained results show the efficiency of the proposed approach.

In the contemporaneous sustainable manufacturing scenario and fourth industrial revolutions, requirements of most cutting-edge CNC machine tools are indispensable for finished products with high accuracy, precision and green complaints in particular. Such requirements have impelled the advanced manufacturing industries to evaluate and choose the proper CNC machine tools for best customized performances. In the face of proper and effective green evaluation, this paper incorporates a heterogeneous expert group based decision framework considering multiple significant technical and green criteria by assessing relative importance of diverse conflicting criteria having substantial contribution in performance analysis of CNC machine tools. As a demonstration of the suggested mathematical model, three real life decision making problems related to 3 axes-CNC machine tools based on the collected quantitative and linguistic data from catalogues, manufacturer’s portals, questionnaires, customer reviews etc. are established. The calculated findings are close to those obtained by previous researchers as well as are verified by well-established techniques. Besides, sensitivity and statistical analysis are performed to examine the robustness and stability of the ranking orders of the alternatives as well as to investigate the efficacy and consistency of the proposed method. Hence thus proposed formulated MCDM approach proves to be a highly effective and reliable decision making tool for choosing the most suitable CNC machine tools.

This paper investigates experimentally and numerically the influence of geometry and loading conditions on the fracture response of rock materials. Seven different test samples namely “Edge-Notched-Disc-Bend (ENDB), Semi-Circular-Bend (SCB), Three-Point-Bend-Inclined-Crack (TPB-IC), Single-Edge-Notched-Bending (SENB), Asymmetric-Three-Point-Bend (ATPB), Edge-Notched-Disc-Compression (ENDC) and Double-Notched-Disc-Compression (DNDC)” made of a marble rock were manufactured and tested under bending and compressive loading conditions. The results showed that the failure loads of all samples increase with the change of pure mode I to pure mode III. However, the corresponding fracture toughness values of ENDB, SCB, TPB-IC, SENB and ATPB specimens decreased, while the ENDC and DNDC samples experienced an increase in the fracture toughness. Among the studied specimens, only the ENDB, ENDC and DNDC samples presented pure mode III with KIIIc/KIc ratio ranging from 0.735 for the ENDB specimen to 2.076 for the DNDC sample. The highest mode-I fracture toughness among all the studied specimens was obtained for the SENB and TPB-IC samples, with a value of 1.54 MPa m0.5, while the lowest value was obtained for the DNDC specimen with a value of 1.21 MPa m0.5. The sign and the magnitude of T-stress considerably depended on the loading condition and geometry of the specimens. The crack trajectories of all specimens under study were also investigated.

Credit risk affects the work and reputation of banks. Islamic banks' heavy reliance on debt financing has led to increased interest in credit risk and its management. This paper aimed to identify the bank-specific factors affecting credit risk in Islamic banks, expressed as Non-Performing Finance NPF in the Middle East for the period 2011-2022. The study was based on a panel data analysis of 30 Islamic banks. The findings of study show a significant negative impact of Return On Assets ROA, Capital Adequacy Ratio CAR and size Z on the credit risk. The findings show a significant positive impact of Finance Loss Provision FLP on the credit risk. The findings also show no impact of Finance Expansion FEX, Finance to Deposit Ratio FDR and Capital Ratio CPR on the credit risk. The study showed that increasing the provision for financing losses and capital adequacy helps banks to reduce the impact of credit risks. The study recommends applying cautious lending policies and carefully selecting clients.

Human migration is based on pull factors that individuals evaluate when it comes to moving to a different territory. Likewise, employee attrition is a phenomenon that represents the tendency to a reduction in employees within an organization. This research paper aims to develop and evaluate machine learning algorithms, namely Decision Tree, Random Forest, and Binary Logistic Regression, to predict employee attrition using the IBM dataset available on Kaggle. The objective is to provide organizations with a proactive approach to employee retention and human resource management by creating accurate predictive models. Employee attrition has significant implications for an organization's reputation, profitability, and overall structure. By accurately predicting employee attrition, organizations can identify the factors contributing to it and implement data-driven human resources management practices. This study contributes to improving decision-making processes, including hiring and firing decisions, and ultimately enhances an organization's capital. The IBM dataset used in this study consists of anonymized employee records and their employment outcomes. It provides a comprehensive HR data representation for analysis and prediction. Three machine learning algorithms, Decision Tree, Random Forest, and Binary Logistic Regression, were utilized in this research. These algorithms were selected for their potential to improve accuracy in predicting employee attrition. The Logistic Regression model yielded the highest accuracy of 87.44% among the tested algorithms. By leveraging this study's findings, organizations can develop predictive models to identify factors contributing to employee attrition. These insights can inform strategic decisions and optimize human resource management practices.

Methyl α-D-mannopyranoside (MAM) is a naturally occurring carbohydrate derivative that has gained attention in drug discovery due to its potential therapeutic applications, particularly as an antifungal agent. In this study, we employed a computational approach to investigate the interactions between MAM and two Candida albicans antifungal proteins, 1IYL and 1AI9, through molecular docking simulations. Furthermore, we performed a PASS (Prediction of Activity Spectra for Substances) analysis to predict MAM potential biological activities, explored the pharmacokinetic properties and ADMET (absorption, distribution, metabolism, excretion, and toxicity) profiles, and optimized the MAM using the density functional theory (DFT) method. The molecular docking results revealed favorable binding interactions between MAM and the active sites of the 1IYL and 1AI9 proteins, suggesting potential antifungal activity. Additionally, the ADMET profiles indicated low toxicity and suitable drug-like properties, such as moderate metabolic stability and minimal risk of adverse effects. Furthermore, DFT optimization was performed to investigate the molecular geometry and electronic properties of MAM. The optimization results provided valuable information on the stability and reactivity of MAM, enabling a better understanding of its chemical behavior and potential modifications for enhanced activity. Finally, PASS prediction was employed to evaluate MAM's potential biological activities beyond its antifungal properties. The analysis revealed several potential activities, including antibacterial, antiviral, and immunomodulatory effects, expanding the scope for future research and therapeutic applications. In conclusion, this computational study sheds light on the molecular interactions, pharmacokinetic properties, ADMET profiles, DFT optimization, and PASSES predictions of MAM. These findings highlight the potential of MAM as a promising antifungal agent with favorable pharmacological properties.

Expressive suppression is the process of decreasing, increasing, or maintaining emotional intensity over a period of time. It is employed as an immediate response to emotional stimuli and can result in negative psychological outcomes. This emotional regulation process can be harmful in the workplace, especially when one considers time pressures and the standard corporate hierarchical structure in modern America, which potentially also introduces stress into situations due to the “superior/subordinate” relationship. This study analyzed the correlation between self-reported high usage of expressive suppression and perceived stress and found that a correlation does exist between the emotion regulation technique and perceived stress. The study also reviewed other workplace situations and found that being in the presence of a superior also plays a role in this dynamic. The study highlights the stress impact of employing expressive suppression and the need for further research into factors within the workplace that impact an individual’s emotional regulation and impact overall stress.