In this work, we studied the problem of thermoelastic diffusion beams on the basis of modified couple stress theory under the effects of two temperature and laser pulse. The Euler-Bernoulli beam theory and the Laplace transform technique are applied to solve the basic equations of thermoelastic diffusion in the non-dimensional form. The transformed components of displacement, lateral deflection, axial stress, temperature change, concentration, and chemical potential are calculated mathematically to solve the problem. Copper material is used to prepare the mathematical model. The general algorithm of the inverse Laplace transform technique has been calculated numerically. MATLAB software is used to find the results numerically and depict them graphically. The effects of two temperature, laser pulse, and couple stress are presented graphically on the physical quantities. Particular cases are also discussed in the present problem. Laser pulse has many applications in Heat treatment, cutting of plastics, glasses, ceramics, semiconductors and metals, surgery, Lithography, and welding.

Flibanserin (Addyi) is a medication used to treat women who have not gone through menopause who have low sexual desire. Specific and simple stability indicating method was developed and validated by high-performance liquid chromatography (RP-HPLC) for the determination of Flibanserin. Separation was carried out by using a mobile phase consisting of 0.01M Potassium phosphate monohydrate buffer (KH₂PO₄) pH 3.50 buffer: Acetonitrile in the ratio of 60:40. The column used was Agilent C18, (150×4.6) mm, 5µm with a flow rate of 1.0ml/min and temperature at 30°C. The detection was carried out at 248 nm and Flibanserin was eluted at around 2.8min. This method was validated as per ICH guidelines and validation included specificity, precision, linearity, accuracy, forced degradation, and robustness. Forced degradation was conducted under the conditions of hydrolysis, oxidation, thermal, acid, base, and peroxide hydrolysis. The calibration curve was linear over the concentration range from 20 to 200µg/mL and the coefficient of determination (r²) was observed as 0.9998. The precision and accuracy of the method were within the acceptable range. The results of this study showed that the validated method is simple and accurate, which confirmed that the method is suitable for the determination of Flibanserin.

The present manuscript describes an in-depth analysis of various interactions present in the crystal structure of formyl coumarins using Crystal explorer 17.0. Element based interactions were quantified by the decomposition of generated 3D surfaces into 2D fingerprint regions. DFT methods were used to explore electrostatic parameters, global and local reactivity descriptors. Electrophilicity based charge transfer (ECT) analysis was done to explore the probability of charge transfer between formyl coumarins and DNA base pairs. The reactivity and selectivity of different formyl coumarins have been accessed using Fukui functions in their reduced form. Non-bonding orbital (NBO) analysis revealed the presence of various hyperconjugative interactions and their stabilization energy in formyl coumarins. Non-linear optical properties are presented in terms of first order hyperpolarizibility (β₀), where maximum β₀ is observed for C4 (1.64 × 10-30esu.) which is found to be 2 times greater than that of p-nitroaniline. Molecular electrostatic potential (MEP) plots are mapped in terms of electron density.

The main goal of this research is to compare the various optimization strategies (Response Surface Methodology, Taguchi, and Teaching Learning Based Optimization) for orthogonal turning of Hard to Machine materials. The workpiece material in this work is Ti6Al4V alloys. After selecting cutting speeds in the High-Speed Machining range, orthogonal turning tests are performed on the material for a specific combination of machining parameters – Depth of Cut, Cutting Speed, and, Feed Rate. A Lathe Tool Dynamometer is used to record the cutting forces from the trials. After combining Johnson Cook Material and Damage models, a comprehensive Finite Element Model is created to model the Orthogonal Turning of Ti6Al4V alloys. Experiments conducted previously validate the developed model. Three different strategies, namely RSM, Taguchi, and TLBO, were used to optimise machining parameters for minimal Cutting Force. The approaches are compared for the best combination of machining parameters and the best Cutting Force value. Analysis of Variance is used to study the impact of machining factors on Cutting Force.

Analyzing a drug over its overlapped spectra utilizes sophisticated instruments and more toxic solvents, which has a deleterious effect on environmental safety. There is an alarming need to develop a simple, novel, and cost-effective method for determining combined substances that are non-toxic to the environment. So, the study aimed to develop four simple, fast and eco-friendly spectrophotometric techniques for quantifying clotrimazole and tinidazole in bulk and ointment dosage form. Stock solutions produced at concentrations of 7 to 13 and 17.5 to 32.5 µg/mL of clotrimazole and tinidazole in 10% v/v ethanol and scanned in the UV-visible range 200-450 nm, and used for all methods. The methods were validated according to the International Council for Harmonization guidelines and found to be within limits. Additionally, the outliers were tested by using the Grubbers test and found within limits. Finally, green evaluation studies show that the method is more environmentally friendly, as confirmed by four assessment tools.

The decision to purchase the best available electric power wheelchair (EPWC) for a person with a disability in a low-resource context is very stressful, whether it is based on financial circumstances or the availability of medical solutions. The study's objective is to assess the EPWC options available on the market, focused on a set of conflicting criteria. In this research, three multi-criteria decision-making (MCDM) approaches are used to make decisions. ENTROPY method for weightage calculation of various parameters, COPRAS and EDAS methods for evaluating and ranking alternatives are applied. Both COPRAS and EDAS are applied separately for ranking of selected wheelchair models, and to check the robustness of the applied method, sensitivity analysis on cost criterion is carried out. The result shows that for both methods, EPWC-1 is the top priority model to buy, whereas EPWC-7 is the worst model for COPRAS, and EPWC-10 is the worst model for EDAS among the ten alternatives.

In this study, Carbon, Glass, and Aramid fiber reinforced composite and their hybridized forms were fabricated using five different stacking sequences of the fabrics. Using the Vacuum Assisted Resin Transfer Molding (VARTM) procedure, epoxy resin was injected into these fabrics and allowed to cure at room temperature. From these five stacking sequences, a standard specimen with four different orientations viz. 0/90°, 15/75°, 30/60°, 45/-45° orientations were obtained using the Abrasive Water Jet Machining(AWJM) Process. The influence of stacking order and fiber orientation on tensile and flexural properties of composite was investigated. From the result of tensile testing, the highest and lowest tensile strength values were observed for neat carbon fiber reinforced composite at 0/90° orientation and at 45/-45° orientation respectively. The highest flexural strength was achieved in a hybrid combination of two layers of carbon, glass and aramid fabric for 0/90° whereas the lowest flexural strength was found in glass reinforced composite for the 45/-45° orientation.

In this paper, we propose the binary version of the Social Group Optimization (BSGO) algorithm for solving the 0-1 knapsack problem. The standard Social Group Optimization (SGO) is used for continuous optimization problems. So a transformation function is used to convert the continuous values generated from SGO into binary ones. The experiments are carried out using both low-dimensional and high-dimensional knapsack problems. The results obtained by the BSGO algorithm are compared with other binary optimization algorithms. Experimental results reveal the superiority of the BSGO algorithm in achieving a high quality of solutions over different algorithms and prove that it is one of the best finding algorithms especially in high-dimensional cases.

A convenient and efficient synthesis of a series of ethyl-1-(6-(4-substitutedacetylatedpiperazin-1-yl)pyrimidin-4-yl)-5-amino-1H-pyrazole-4-carboxylate (8a-8j) has been developed by five steps which include activation of a methylene group, hydrazinolysis, cyclisation and chloro-amine coupling reactions. Moreover, our proposed mechanism was confirmed in this study demonstrating that ethyl 5-amino-1-(6-chloropyrimidin-4-yl)-1H-pyrazole-4-carboxylate is the key intermediate to fulfill the desired outcomes. In silico and in vitro studies were carried out to identify the active agents among the developed adducts against mycobacterium tuberculosis (PDB ID:4TRO). Compound 8a (Docking Score: -26.81 and MIC: 1.6 ug/mL) was found to be the most potent among the synthesized molecules. All the synthesized compounds showed acceptable drug-like properties which make them suitable for further lead modification using in silico design approaches.

The increasing demand for good and improved polymeric composites has led to a surge in the number of researches on hybrid composites, strengthened and enforced with the natural fibres. This paper mainly analyses and presents the attributes of hybrid composites made from natural fibres and carbon nano-tube (CNT) nanoparticles. A novel hybrid composite considered in this research includes kenaf and coir fibres with CNT nanoparticles embedded in an epoxy matrix. The proposed hybrid nanocomposite’s elastic features are calculated by using different analytical models like Chamis, Mori-Tanaka, Nielson elastic models etc and also with the help of Representative Volume Element Analysis (RVE). The content of fibre volume is varied in four different samples and it is found that upon varying the content of fibre volume, the mechanical properties like longitudinal modulus and transverse modulus got affected. The results evaluated from different analytical models are observed to be in good agreement with each other and also with the results of RVE analysis.