Synthesis and anticancer properties of 3-furan-2-yl-2-(4-furan/thiophen-2-ylthiazol-2-yl)acrylonitrile derivatives

Matiichuk, Y.; Horak, Y.; Chaban, T.; Chaban, I.; Matiychuk, V.

Growing Science » Current Chemistry Letters » Synthesis and anticancer properties of 3-furan-2-yl-2-(4-furan/thiophen-2-ylthiazol-2-yl)acrylonitrile derivatives

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Current Chemistry Letters

ISSN 1927-730x (Online) - ISSN 1927-7296 (Print) Quarterly Publication Volume 11 Issue 3 pp. 269-274 , 2022

Synthesis and anticancer properties of 3-furan-2-yl-2-(4-furan/thiophen-2-ylthiazol-2-yl)acrylonitrile derivatives Pages 269-274 Download PDF

Authors: Yulia Matiichuk, Yuriy Horak, Taras Chaban, Ihor Chaban, Vasyl Matiychuk

DOI: 10.5267/j.ccl.2022.4.002

Keywords: Arylation, Thiazol, Furan, Thiophen, Anticancer Activity

Abstract: Spodopetra Frugiperda is a highly polyphagous migratory lepidopteran pest species. It causes infestation in crops leading to severe crop losses. Being a new invasive parasite, its susceptibility to insecticides needs to be explored and therefore, there is an urgent need to develop the potent insecticides for the effective control of this insect pest. This is the first report on toxic effects produced by the prepared chalcone and hydrazone analogs, followed by structure relationships. Five compounds of chalcone and hydrazone derivatives have been synthesized in pure state as reported procedures, and their toxicity as potential insecticidal agent against Spodopetra Frugiperda was screened. Their characterizations by using spectroscopic analyses were performed. The toxicity data exhibited that compound 5 is more toxic about 2-fold than other synthesized compounds, the other screened compounds showed weak to strong toxicological activity against Spodopetra Frugiperda (lepidoptera: Noctuidae).

How to cite this paper

 Matiichuk, Y., Horak, Y., Chaban, T., Chaban, I & Matiychuk, V. (2022). Synthesis and anticancer properties of 3-furan-2-yl-2-(4-furan/thiophen-2-ylthiazol-2-yl)acrylonitrile derivatives.Current Chemistry Letters, 11(3), 269-274.

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