Amidoalkylation of heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]- 2'-chloroacetamide and antimicrobial activity of derivatives

Toshmurodov, T.; Ziyaev, A.; Sasmakov, S.; Abdurakhmanov, J.; Ziyaeva, M.; Ismailova, D.; Azimova, S.

Growing Science » Current Chemistry Letters » Amidoalkylation of heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]- 2'-chloroacetamide and antimicrobial activity of derivatives

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Current Chemistry Letters

ISSN 1927-730x (Online) - ISSN 1927-7296 (Print) Quarterly Publication Volume 10 Issue 4 pp. 427-434 , 2021

Amidoalkylation of heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]- 2'-chloroacetamide and antimicrobial activity of derivatives Pages 427-434 Download PDF

Authors: Turdibek Toshmurodov, Abdukhakim Ziyaev, Sobirdjan Sasmakov, Jaloliddin Abdurakhmanov, Mavluda Ziyaeva, Dilnoza Ismailova, Shakhnoz Azimova

DOI: 10.5267/j.ccl.2021.5.002

Keywords: N-[5-(alkylsulfanyl)-1, 3, 4-thiadiazol-2-yl]-2-chloroacetamide, Pyperidine, Morpholine, Cytisine, Antimicrobial activity

Abstract: Amidoalkylation of secondary heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]-2'-chloroacetamide resulted the new compounds 5-10 that contain 1,3,4-thiadiazole-5-thione moiety alongside pyperidine, morpholine, and cytisine fragments. In vitro screening of antimicrobial activity of synthesized compounds showed that N-[5-(amylsulfanyl)-1,3,4-thiadiazol-2-yl]-2'-morpholinacetamide exhibited an appreciable antibacterial activity against gram-negative bacteria of Escherichia coli (inhibition zone diameter of 16 mm) and gram-positive bacteria of Staphylococcus aureus and Bacillus subtilis (10-13 mm).

How to cite this paper

 Toshmurodov, T., Ziyaev, A., Sasmakov, S., Abdurakhmanov, J., Ziyaeva, M., Ismailova, D & Azimova, S. (2021). Amidoalkylation of heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]- 2'-chloroacetamide and antimicrobial activity of derivatives.Current Chemistry Letters, 10(4), 427-434.

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