How to cite this paper
Moubeen, S., El-Shahat, M., Aziz, A & Attia, A. (2021). Synthesis, characterization and biological evaluation of novel octahedral Ru(III) complexes containing pentadentate Schiff base ligands.Current Chemistry Letters, 10(1), 17-32.
Refrences
1 Jakupec M.A., Galanski M, Arion V.B., Hartinger C.G., and Keppler B.K. (2008) Antitumour metal compounds: more than theme and variations. Dalton Trans. 2, 183-194.
2 Nehru S., Veeralakshmi S. Kalaiselvam S. David S.P.S. Sandhya J., and Arunachalam S. (2020) Protein binding and antioxidant studies of diimine based emissive surfactant-ruthenium(II) complexes. J. Biomol. Struct. Dyn. Accepted Manuscript (DOI: 10.1080/07391102.2020.1733664).
3 Bruijnincx P.C., and Sadler P.J. (2008) New Trends for Metal Complexes with Anticancer Activity. J. Curr. Opin. Chem. Biol., 12 (2), 197-206.
4 Tripathi L., Kumar P., and Singhai A.K. (2007) Role of chelates in treatment of cancer. Indian J. Cancer, 44 (2), 62-71.
5 Markman M. (2003) Toxicities of the platinum antineoplastic agents. Expert. Opin. Drug Saf., 2 (6) 597-607.
6 Dasari S., and Tchounwou P.B. (2014) Cisplatin in Cancer Therapy: Molecular Mechanisms of Action. Eur. J. Pharmacol., 740, 364-378.
7 Sankarganesh M., Raja J.D., Revathi N., Solomon R.V., and Kumar R.S. (2019) Gold(III) complex from pyrimidine and morpholine analogue Schiff base ligand: Synthesis, characterization, DFT, TDDFT, catalytic, anticancer, molecular modeling with DNA and BSA and DNA binding studies. J. Mol. Liq., 294, 111655-111665.
8 Ahamad M.N., Iman K., Raza M.K., Kumar M., Ansari A., Ahmad M., and Shahid M. (2020) Anticancer properties, apoptosis and catecholase mimic activities of dinuclear cobalt(II) and copper(II) Schiff base complexes. Bioorg. Chem., 95, 103561-103575.
9 Keypour H., Ansari N., Mahmoudabadi M., Karamian R., Farida S.H.M., Moghadam M.E., and Gable, R.W. (2020) Mn(III), Zn(II) and Pt(II) macroacyclic complexes: synthesis, X-ray structures, anticancer and antioxidant activities. Inorg. Chim. Acta, 509, 119705-119714.
10 Abdel Aziz A.A., and Sayed M.A. (2020) Some novel rare earth metal ions complexes: Synthesis, characterization, luminescence and biocidal efficiency. Anal. Biochem., 598, 113645.
11 Kostova I. (2006) Ruthenium complexes as anticancer agents. Curr. Med. Chem., 13 (9), 1085-1107.
12 Scintilla S., Brustolin L., Gambalunga A., Chiara F., and Fregona D. (2016) Ru(III) anticancer agents with aromatic and non-aromatic dithiocarbamates as ligands: Loading into nanocarriers and preliminary biological studies. J. Inorg. Biochem., 165, 159-169.
13 Sahyon H.A., El-Bindary A.A., Shoair A.F., and Abdellatif A.A. (2018) Synthesis and characterization of ruthenium(III) complex containing 2-aminomethyl benzimidazole, and its anticancer activity of in vitro and in vivo models. J. Mol. Liq., 255, 122-134.
14 Gramni L., Vukea N., Chakraborty A., Samson W.J., Dingle L.M.K.,. Xulu B., Mare J-A., Edkins A.L., and Booysen I.N. (2019) Anticancer evaluation of ruthenium(III) complexes with N-donor ligands tethered to coumarin or uracil moieties. Inorg. Chim. Acta, 492, 98-107.
15 Askari B., Rudbari H. A., Micale N., Schirmeister T., Maugeri, A. and Navarra M. (2019) Anticancer study of heterobimetallic platinum(II)-ruthenium(II) and platinum(II)-rhodium(III) complexes with bridging dithiooxamide ligand. J. Organomet. Chem. 900, 120918-120926.
16 Abouzayed F.I., Emam S.M., and Abouel-Enein S.A. (2020) Synthesis, characterization and biological activity of nano-sized Co(II), Ni(II), Cu(II), Pd(II) and Ru(III) complexes of tetradentate hydrazone ligand. J. Mol. Struct., 1216, 128314-128325.
17 Pradhan A.K., and Mondal P. (2020) Quantum chemical investigation on the interaction of cysteine and DNA purine bases with aquated ruthenium(III) anticancer drug (ImH)[trans-RuCl4(Im)2]. Comp. Theor. Chem., 1172, 112664.
18 Suchithr R., Sounthari P., Kiruthika A., Chitra S., Parameswari K., and Vijitha J. (2016) Ru (III) Azo Schiff Base Complexes: Synthesis, Spectral Characterization, Antimicrobial and Anticancer Studies. Int. J. Pharm. Sci. Res., IJPSR 6 (3), 1283-1293.
19 Çapan A., Uruş S., and Sönmez M. (2018) Ru(III), Cr(III), Fe(III) Complexes of Schiff Base Ligands Bearing Phenoxy Groups: Application as Catalysts in The Synthesis of Vitamin K3. J. Saudi. Chem. Soc., 22 (6), 757-766.
20 Geary W.J. (1971) The use of conductivity measurements in organic solvents for the characterisation of coordination compounds. Coord. Chem. Rev., 7, 81-122.
21 Dabbagh H.A., Teimouri A., Chermahini A.N., and Shahraki M. (2008) DFT and Ab initio study of structure of dyes derived from 2-Hydroxy and 2,4-Dihydroxy benzoic acids. Spectrochim Acta A, 69 (2), 449-4591.
22 Ünver H., Boyacıoglu B., Zeyrek C.T., Yıldız M., Demir N., Yıldırım N., Karaosmanoglu O., Sivas H., and Elmalı A. (2016) Synthesis, spectral and quantum chemical studies and use of (E)-3- [(3, 5-bis (trifluoromethyl)phenylimino)methyl]benzene-1, 2-diol and its Ni (II) and Cu (II) complexes as an anion sensor, DNA binding, DNA cleavage, anti-microbial, anti-mutagenic and anti-cancer agent. J. Mol. Struct., 1125, 162-176.
23 Ejidike I.P., and Ajibade A. (2016) Ruthenium(III) Complexes of Heterocyclic Tridentate (ONN) Schiff Base: Synthesis, Characterization and its Biological Properties as an Antiradical and Antiproliferative Agent. Int. J. Mol. Sci., 17 (1), 1-12.
24 Ramadan R.M., Elantabli F.M., and El-Medani S.M. (2019) Conversion of thiol to homodisulfide-Schiff base derivative: Synthesis, molecular structure, crystal structure and DFT studies. J. Mol. Struct., 1196, 547-554.
25 Shoair A.F., El-Shobaky A.R., and Abo-Yassin H.R. (2015) Synthesis, spectroscopic characterization, catalytic and antibacterial studies of ruthenium(III) Schiff base complexes. J. Mol. Liq., 211, 217-227.
26 Thangadurai T.D., and Natarajan K. (2001) Synthesis and Characterization of New Ruthenium(iii) Complexes Containing Tetradentate Schiff Bases. Synth. React. Inorg. Met-Org. Chem., 31 (4), 549-567.
27 İspir E., Kurtoğlu M., and Toroğlu S. (2006) The d10 Metal Chelates Derived from Schiff Base Ligands Having Silane: Synthesis, Characterization, and Antimicrobial Studies of Cadmium(II) and Zinc(II) Complexes. Synth. React. Inorg. Met-Org. Chem., 36 (8), 627-631.
28 Thangadurai T.D., and Ihm S.K. (2005) Ruthenium(II) Complexes Derived from Substituted Cyclobutane and Substituted Thiazole Schiff Base Ligands: Synthetic, Spectral, Catalytic and Antimicrobial Studies. Synth. React. Inorg. Met-Org. Chem., 35 (6), 499-507.
29 Manjunath M., Kulkarni A.D., Bagihalli G.B., Malladi S., and Patil S.A. (2017) Bio-important antipyrine derived Schiff bases and their transition metal complexes, synthesis, spectroscopic characterization, antimicrobial, anthelmintic and DNA cleavage investigation. J. Mol. Struct., 1127, 314-321.
30 Buldurun K., Turan N., Savcı A., and Çolak N. (2019) Synthesis, structural characterization and biological activities of metal(II) complexes with Schiff bases derived from 5-bromosalicylaldehyde: Ru(II) complexes transfer hydrogenation. J. Saudi Chem. Soc., 23 (2), 205-214.
31 Khan M.M.T., Srinivas D., Kureshy R.I., and Khan N.H. (1990) Synthesis, Characterisation and EPR Studies of Stable Ruthenium(III) Schiff Base Chloro and Carbonyl Complexes. Inorg. Chem., 29 (120), 2320-2326.
32 Thangadurai T.D., Gowri M., and Natarajan K. (2002) Synthesis and Characterisation Of Ruthenium(iii) Complexes Containing Monobasic Bidentate Schiff Bases And Their Biological Activities. Synth. React. Inorg. Met-Org. Chem., 32 (2), 329-343.
33 Aly S.A. (2018) Physico-chemical study of new ruthenium(III), Pd(II) and Co(II) complexes, DNA binding of Pd(II) complex and biological applications. J. Rad. Res. App. Sci., 11 (3), 163-170.
34 Patel M.N., Gandhi D.S., Parmar P.A., and Joshi H.N. (2012) DNA-binding and cleavage activity of polypyridyl ruthenium(II) complexes. J. Coord. Chem., 65 (11), 1926-1936.
35 Shobana S., Subramaniam P., Mitu L., Dharmaraja J., and Narayan S.A. (2015) Synthesis, structural elucidation, biological, antioxidant and nuclease activities of some 5-Fluorouracil–amino acid mixed ligand complexes. Spectrochim. Acta A, 134, 333-344.
36 Abd-Elzar M.M. (2001) Spectroscopic Characterization of Some Tetradentate Schiff Bases and Their Complexes with Nickel, Copper and Zinc. J. Chin. Chem. Soc., 48 (2), 153-158.
37 Sathiyaraj S., Butcher R.J., and Jayabalakrishnan C. (2013) DNA interaction and cytotoxicity studies of ruthenium(III) complexes containing 3-(benzothiazol-2-yliminomethyl)-naphthalen-2-ol ligand. J. Coord. Chem., 66 (4), 580-591.
38 Alonso, A., Almendral, M. J., Curto, Y., Criado, J.J., Rodríguez, E., and Manzano, J.L. (2007) New Fluorescent Antitumour Cisplatin Analogue Complexes. Study of the Characteristics of their Binding to DNA by Flow Injection Analysis. J. Fluoresc., 17 (4), 390-400.
39 Pandya S.B., Patel U.H, and Chaudhary K.P., Socha B.N., Patel N.J., and Bhatt B.S. (2019) DNA interaction, cytotoxicity and molecular structure of cobalt complex of 4‐amino‐N‐(6‐chloropyridazin‐3‐yl) benzene sulfonamide in the presence of secondary ligand pyridine. App. Organomet. Chem., 33 (12), e5235.
40 Sun J., Hao H., Lin H., Liu X., Zhong D., and Chen W. (2012) Synthesis and Crystal Structure of a New Ru(II) Complex With Dicationic 2,2′-Dipyridyl Derivatives as Ligand. Synth. React. Inorg. Met-Org. Chem.,, 42 (6), 801-804.
41 Reinert K,E, (1973) DNA stiffening and elongation caused by the binding of ethidium bromide. Biochim. Biophys. Acta, 319, 135-139.
42 Gao F., Chao H., Zhou F., Yuan Y.X., Peng B., and Ji L.N. (2006) DNA interactions of a functionalized ruthenium(II) mixed-polypyridyl complex [Ru(bpy)2ppd]2+. J. Inorg. Biochem., 100 (9), 1487-1494.
43 Ramana N., Sobhaa S., T and hamaraichelvan A. (2011) A novel bioactive tyramine derived Schiff base and its transition metal complexes as selective DNA binding agents. Spectrochim. Acta A, 78 (20), 888-898.
44 Muralisankar M., Haribabu J., Bhuvanesh N.S.P., and Karvembu R., and Sreekanth A. (2016) Synthesis, X-ray crystal structure, DNA/protein binding, DNA cleavage and cytotoxicity studies of N (4) substituted thiosemicarbazone based copper (II)/nickel (II) complexes. Inorg. Chim. Acta, 449 (3), 82-95.
45 Ejidike I.P., and Ajibade P.A. (2015) Synthesis, characterization, and in vitro antioxidant and anticancer studies of ruthenium(III) complexes of symmetric and asymmetric tetradentate Schiff bases. J. Coord. Chem., 68 (14), 2552-2564.
46 Sáez R., Lorenzo J., Prietoc M.J., Font-Bardia M., Calvet T., Omeñaca N., Vilaseca M., and Moreno V. (2014) Influence of PPh3 moiety in the anticancer activity of new organometallic ruthenium complexes. J. Inorg. Biochem,. 136, 1-12.
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2 Nehru S., Veeralakshmi S. Kalaiselvam S. David S.P.S. Sandhya J., and Arunachalam S. (2020) Protein binding and antioxidant studies of diimine based emissive surfactant-ruthenium(II) complexes. J. Biomol. Struct. Dyn. Accepted Manuscript (DOI: 10.1080/07391102.2020.1733664).
3 Bruijnincx P.C., and Sadler P.J. (2008) New Trends for Metal Complexes with Anticancer Activity. J. Curr. Opin. Chem. Biol., 12 (2), 197-206.
4 Tripathi L., Kumar P., and Singhai A.K. (2007) Role of chelates in treatment of cancer. Indian J. Cancer, 44 (2), 62-71.
5 Markman M. (2003) Toxicities of the platinum antineoplastic agents. Expert. Opin. Drug Saf., 2 (6) 597-607.
6 Dasari S., and Tchounwou P.B. (2014) Cisplatin in Cancer Therapy: Molecular Mechanisms of Action. Eur. J. Pharmacol., 740, 364-378.
7 Sankarganesh M., Raja J.D., Revathi N., Solomon R.V., and Kumar R.S. (2019) Gold(III) complex from pyrimidine and morpholine analogue Schiff base ligand: Synthesis, characterization, DFT, TDDFT, catalytic, anticancer, molecular modeling with DNA and BSA and DNA binding studies. J. Mol. Liq., 294, 111655-111665.
8 Ahamad M.N., Iman K., Raza M.K., Kumar M., Ansari A., Ahmad M., and Shahid M. (2020) Anticancer properties, apoptosis and catecholase mimic activities of dinuclear cobalt(II) and copper(II) Schiff base complexes. Bioorg. Chem., 95, 103561-103575.
9 Keypour H., Ansari N., Mahmoudabadi M., Karamian R., Farida S.H.M., Moghadam M.E., and Gable, R.W. (2020) Mn(III), Zn(II) and Pt(II) macroacyclic complexes: synthesis, X-ray structures, anticancer and antioxidant activities. Inorg. Chim. Acta, 509, 119705-119714.
10 Abdel Aziz A.A., and Sayed M.A. (2020) Some novel rare earth metal ions complexes: Synthesis, characterization, luminescence and biocidal efficiency. Anal. Biochem., 598, 113645.
11 Kostova I. (2006) Ruthenium complexes as anticancer agents. Curr. Med. Chem., 13 (9), 1085-1107.
12 Scintilla S., Brustolin L., Gambalunga A., Chiara F., and Fregona D. (2016) Ru(III) anticancer agents with aromatic and non-aromatic dithiocarbamates as ligands: Loading into nanocarriers and preliminary biological studies. J. Inorg. Biochem., 165, 159-169.
13 Sahyon H.A., El-Bindary A.A., Shoair A.F., and Abdellatif A.A. (2018) Synthesis and characterization of ruthenium(III) complex containing 2-aminomethyl benzimidazole, and its anticancer activity of in vitro and in vivo models. J. Mol. Liq., 255, 122-134.
14 Gramni L., Vukea N., Chakraborty A., Samson W.J., Dingle L.M.K.,. Xulu B., Mare J-A., Edkins A.L., and Booysen I.N. (2019) Anticancer evaluation of ruthenium(III) complexes with N-donor ligands tethered to coumarin or uracil moieties. Inorg. Chim. Acta, 492, 98-107.
15 Askari B., Rudbari H. A., Micale N., Schirmeister T., Maugeri, A. and Navarra M. (2019) Anticancer study of heterobimetallic platinum(II)-ruthenium(II) and platinum(II)-rhodium(III) complexes with bridging dithiooxamide ligand. J. Organomet. Chem. 900, 120918-120926.
16 Abouzayed F.I., Emam S.M., and Abouel-Enein S.A. (2020) Synthesis, characterization and biological activity of nano-sized Co(II), Ni(II), Cu(II), Pd(II) and Ru(III) complexes of tetradentate hydrazone ligand. J. Mol. Struct., 1216, 128314-128325.
17 Pradhan A.K., and Mondal P. (2020) Quantum chemical investigation on the interaction of cysteine and DNA purine bases with aquated ruthenium(III) anticancer drug (ImH)[trans-RuCl4(Im)2]. Comp. Theor. Chem., 1172, 112664.
18 Suchithr R., Sounthari P., Kiruthika A., Chitra S., Parameswari K., and Vijitha J. (2016) Ru (III) Azo Schiff Base Complexes: Synthesis, Spectral Characterization, Antimicrobial and Anticancer Studies. Int. J. Pharm. Sci. Res., IJPSR 6 (3), 1283-1293.
19 Çapan A., Uruş S., and Sönmez M. (2018) Ru(III), Cr(III), Fe(III) Complexes of Schiff Base Ligands Bearing Phenoxy Groups: Application as Catalysts in The Synthesis of Vitamin K3. J. Saudi. Chem. Soc., 22 (6), 757-766.
20 Geary W.J. (1971) The use of conductivity measurements in organic solvents for the characterisation of coordination compounds. Coord. Chem. Rev., 7, 81-122.
21 Dabbagh H.A., Teimouri A., Chermahini A.N., and Shahraki M. (2008) DFT and Ab initio study of structure of dyes derived from 2-Hydroxy and 2,4-Dihydroxy benzoic acids. Spectrochim Acta A, 69 (2), 449-4591.
22 Ünver H., Boyacıoglu B., Zeyrek C.T., Yıldız M., Demir N., Yıldırım N., Karaosmanoglu O., Sivas H., and Elmalı A. (2016) Synthesis, spectral and quantum chemical studies and use of (E)-3- [(3, 5-bis (trifluoromethyl)phenylimino)methyl]benzene-1, 2-diol and its Ni (II) and Cu (II) complexes as an anion sensor, DNA binding, DNA cleavage, anti-microbial, anti-mutagenic and anti-cancer agent. J. Mol. Struct., 1125, 162-176.
23 Ejidike I.P., and Ajibade A. (2016) Ruthenium(III) Complexes of Heterocyclic Tridentate (ONN) Schiff Base: Synthesis, Characterization and its Biological Properties as an Antiradical and Antiproliferative Agent. Int. J. Mol. Sci., 17 (1), 1-12.
24 Ramadan R.M., Elantabli F.M., and El-Medani S.M. (2019) Conversion of thiol to homodisulfide-Schiff base derivative: Synthesis, molecular structure, crystal structure and DFT studies. J. Mol. Struct., 1196, 547-554.
25 Shoair A.F., El-Shobaky A.R., and Abo-Yassin H.R. (2015) Synthesis, spectroscopic characterization, catalytic and antibacterial studies of ruthenium(III) Schiff base complexes. J. Mol. Liq., 211, 217-227.
26 Thangadurai T.D., and Natarajan K. (2001) Synthesis and Characterization of New Ruthenium(iii) Complexes Containing Tetradentate Schiff Bases. Synth. React. Inorg. Met-Org. Chem., 31 (4), 549-567.
27 İspir E., Kurtoğlu M., and Toroğlu S. (2006) The d10 Metal Chelates Derived from Schiff Base Ligands Having Silane: Synthesis, Characterization, and Antimicrobial Studies of Cadmium(II) and Zinc(II) Complexes. Synth. React. Inorg. Met-Org. Chem., 36 (8), 627-631.
28 Thangadurai T.D., and Ihm S.K. (2005) Ruthenium(II) Complexes Derived from Substituted Cyclobutane and Substituted Thiazole Schiff Base Ligands: Synthetic, Spectral, Catalytic and Antimicrobial Studies. Synth. React. Inorg. Met-Org. Chem., 35 (6), 499-507.
29 Manjunath M., Kulkarni A.D., Bagihalli G.B., Malladi S., and Patil S.A. (2017) Bio-important antipyrine derived Schiff bases and their transition metal complexes, synthesis, spectroscopic characterization, antimicrobial, anthelmintic and DNA cleavage investigation. J. Mol. Struct., 1127, 314-321.
30 Buldurun K., Turan N., Savcı A., and Çolak N. (2019) Synthesis, structural characterization and biological activities of metal(II) complexes with Schiff bases derived from 5-bromosalicylaldehyde: Ru(II) complexes transfer hydrogenation. J. Saudi Chem. Soc., 23 (2), 205-214.
31 Khan M.M.T., Srinivas D., Kureshy R.I., and Khan N.H. (1990) Synthesis, Characterisation and EPR Studies of Stable Ruthenium(III) Schiff Base Chloro and Carbonyl Complexes. Inorg. Chem., 29 (120), 2320-2326.
32 Thangadurai T.D., Gowri M., and Natarajan K. (2002) Synthesis and Characterisation Of Ruthenium(iii) Complexes Containing Monobasic Bidentate Schiff Bases And Their Biological Activities. Synth. React. Inorg. Met-Org. Chem., 32 (2), 329-343.
33 Aly S.A. (2018) Physico-chemical study of new ruthenium(III), Pd(II) and Co(II) complexes, DNA binding of Pd(II) complex and biological applications. J. Rad. Res. App. Sci., 11 (3), 163-170.
34 Patel M.N., Gandhi D.S., Parmar P.A., and Joshi H.N. (2012) DNA-binding and cleavage activity of polypyridyl ruthenium(II) complexes. J. Coord. Chem., 65 (11), 1926-1936.
35 Shobana S., Subramaniam P., Mitu L., Dharmaraja J., and Narayan S.A. (2015) Synthesis, structural elucidation, biological, antioxidant and nuclease activities of some 5-Fluorouracil–amino acid mixed ligand complexes. Spectrochim. Acta A, 134, 333-344.
36 Abd-Elzar M.M. (2001) Spectroscopic Characterization of Some Tetradentate Schiff Bases and Their Complexes with Nickel, Copper and Zinc. J. Chin. Chem. Soc., 48 (2), 153-158.
37 Sathiyaraj S., Butcher R.J., and Jayabalakrishnan C. (2013) DNA interaction and cytotoxicity studies of ruthenium(III) complexes containing 3-(benzothiazol-2-yliminomethyl)-naphthalen-2-ol ligand. J. Coord. Chem., 66 (4), 580-591.
38 Alonso, A., Almendral, M. J., Curto, Y., Criado, J.J., Rodríguez, E., and Manzano, J.L. (2007) New Fluorescent Antitumour Cisplatin Analogue Complexes. Study of the Characteristics of their Binding to DNA by Flow Injection Analysis. J. Fluoresc., 17 (4), 390-400.
39 Pandya S.B., Patel U.H, and Chaudhary K.P., Socha B.N., Patel N.J., and Bhatt B.S. (2019) DNA interaction, cytotoxicity and molecular structure of cobalt complex of 4‐amino‐N‐(6‐chloropyridazin‐3‐yl) benzene sulfonamide in the presence of secondary ligand pyridine. App. Organomet. Chem., 33 (12), e5235.
40 Sun J., Hao H., Lin H., Liu X., Zhong D., and Chen W. (2012) Synthesis and Crystal Structure of a New Ru(II) Complex With Dicationic 2,2′-Dipyridyl Derivatives as Ligand. Synth. React. Inorg. Met-Org. Chem.,, 42 (6), 801-804.
41 Reinert K,E, (1973) DNA stiffening and elongation caused by the binding of ethidium bromide. Biochim. Biophys. Acta, 319, 135-139.
42 Gao F., Chao H., Zhou F., Yuan Y.X., Peng B., and Ji L.N. (2006) DNA interactions of a functionalized ruthenium(II) mixed-polypyridyl complex [Ru(bpy)2ppd]2+. J. Inorg. Biochem., 100 (9), 1487-1494.
43 Ramana N., Sobhaa S., T and hamaraichelvan A. (2011) A novel bioactive tyramine derived Schiff base and its transition metal complexes as selective DNA binding agents. Spectrochim. Acta A, 78 (20), 888-898.
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