The objective of this paper is to assess the impact of transactional leadership on supply chain quality management and performance in tourism and travel enterprises in Vietnam. The analysis results were conducted on 298 typical tourism and travel enterprises in Vietnam in 2019. The testing results of the hypotheses show that transactional leadership had a positive impact on supply chain quality management and performance. At the same time, supply chain quality management did not play any full mediate role in the relationship between transactional leadership and performance. However, the qualification level had a statistically significant moderate role in the relationship between transactional leadership and performance. With the more highly qualified leaders, the more transactional leadership is applied, the higher the business performance for tourism and travel enterprises in Vietnam.