This research aims to fill the research gap with empirical evidence that exists about the impact of blockchain and smart inventory systems on supply chain performance in the retail industry in the UAE. The proposed model is uniquely researched as no prior research explores the link between supply chain performances, blockchain, and smart inventory in prestigious academic journals. A quantitative technique with convenient cluster sampling is used. A descriptive, exploratory, causal and analytical design was applied—a sample size of 303 respondents was used for data analysis through regression and hypothesis with ANOVA. The findings revealed a significant positive impact of blockchain and smart inventory systems on SC performance. Limited construct-based research can be focused on more industries and constructs for future studies. There are numerous chances for businesses to leverage blockchain technology to their advantage over the competition, giving them the chance to strengthen their market position. Managers must carefully consider the qualities of their goods, services, and supply chains to ascertain whether they require or would sufficiently benefit from blockchain.