Covid-19 has been causing a large-scale pandemic, along with the rapid development of information technology. Information technology means such as digital applications will be one of the effective tools to help manage public investment and investment in general in Vietnam. Public investment management at autonomous universities in Vietnam is in the final stage of completion in terms of procedures, legal documents, and implementation. This study was designed to shed light on the factors that affect the management of public investments at Vietnamese autonomous universities. The study's data was gathered from a survey of 126 public investment managers at autonomous universities in Vietnam. Factor analysis and multivariate regression methods were used to analyze the influence of factors on public investment management at autonomous universities in Vietnam. According to research findings, the capacity of public investment management agencies at autonomous universities; Distribution of funds for the implementation of public investment projects; administrative procedures, legal provisions, and the actual context affect public investment management at autonomous universities in Vietnam. With Standardized Coefficients = 0.482, distribution of funds for implementation of public investment projects at schools at autonomous universities were the most influential factors. The research results are the foundation for proposing solutions to improve the efficiency of public investment management at these universities in Vietnam such as promulgating legal documents, building public investment management processes suitable to the characteristics of universities, developing, and proactively implementing works in investment management and operating results of public investment in autonomous University.