As an attractive feature for modern transportation systems, the potential of the transfers capability (the load/passenger transfer between the two vehicles in its route) in reducing costs, increasing customer satisfaction and increasing the flexibility of the system, has been approved. But how profitable it could be under different circumstances? In other words, to which factors its influence depends on? what are its benefits versus its costs? The present research aimed to give a relatively comprehensive answer to these questions using a mathematical model of the pickup and delivery system with transfers. According to the model results under different situations, many factors such as modeling assumptions, system goals, transportation network scheme, vehicle fleet in terms of capacity, cost rate, and time window of activity and requests in terms of the length (direct distance between the pickup and delivery points), time windows and the volume to vehicle capacity ratio, affect the transfers benefits. As the small-scale numerical results indicate, we have an average of 5.7% reduction in the trip cost under normal conditions, which increases with the heterogeneity of vehicles, shorter time windows, and an increase in the length of the request. On the other hand, it is expected that profitability increases by problem size.