This study aims to investigate the effect of governance in strengthening the organizational immunity in the Greater Madaba municipality. The study includes two variables, an independent variable, governance and four dimensions including organizational justice, accountability, sustainability, and transparency, and the dependent variable is organizational immunity. The researcher designed a questionnaire consisting of (30) items that included the independent variables, organizational justice, accountability, sustainability, and transparency, and the dependent variable, organizational immunity, and it was distributed to employees of the Greater Madaba municipality, where the researcher used the random sample method, as the size of the study population reached (210) employees. The study used a sample size of 136. The study found a set of results, including the level of both organizational immunity and governance in Greater Madaba municipality, was high, according to the viewpoint of the sample members, and the existence of a statistically significant impact at the level of significance (α ≤ 5%) of governance with its combined dimensions, organizational justice, accountability, sustainability, and transparency, on the organizational immunity in the Greater Madaba municipality. Likewise, the absence of a statistically significant impact at the level of significance (α ≤ 5%) for sustainability was one of the governance dimensions in organizational immunity in Greater Madaba, and there was no effect of transparency on regulatory immunity. The study recommends that the Municipality of Madaba focus on providing programs to develop employees and involve them in training courses in institutes, specialized centers, and universities and pay attention to sustainability and transparency.