This study aimed to investigate factors affecting behavioral intention and use behavior of technologies of Thai people under the COVID-19 circumstances. 390 respondents were participated in our survey as sample size for statistical analysis. The authors utilized PLS-SEM assessment for testing the research hypotheses. Descriptive analysis revealed that Thai people in the quarantine period or work from home had suffered from a moderate to high levels of anxiety or stress. This has made Thai people increasingly use online and mobile technology or programs compared to the past. The study revealed four key factors that had significant and positive effects on the intention of users in using online technology including performance expectancy, effort expectancy, trust, and perceived risk. In addition, it indicated that behavioral intention positively affected the actual use behavior of technologies during quarantine time. The authors expect that policymakers or strategists could be used to manage the use of online and mobile technology for people, especially during the tough time.