Office automation systems play important role on increasing productivity and efficiency of organizations. An automated system is capable of improving required communications, speed up the process of tasks and removes unnecessary activities. This paper presents an empirical investigation to detect important factors influencing on inefficiency of office automation systems in ministry of science, research and technology of Iran. The proposed study of this paper designs a questionnaire and distributes it among management team who work for this organization. The results of our investigation indicate that two factors, lack of necessary infrastructure for participating in office automation activities as well as lack of management support, play important role on reaching desirable results. In addition, educational background and work experience also influence office automation systems’ applicability.