The present study investigates the effectiveness of resilience training on life satisfaction among the mothers with mentally retarded children. The method is semi experimental using pretest posttest with control group. Statistical population of research includes elementary mentally retarded student who were enrolled in Najafabad Sareban exceptional school over the period 2012-2013 educational year. Sample group includes 50 subjects who randomly replaced in control and experimental groups. Experimental group members participated in a 10-session resilience training. Finally, both groups completed post-tests where research scales were Diener life satisfaction questionnaire. The data are analyzed by co-variance analysis test. Results are significant and indicates that resilience training is effective on life satisfaction (p & LT; 0.05).