The purpose of this research is to know the influence of Uncertainty Macroeconomic and demographic factors such as Population, Gross Domestic Product, Government Sukuk and Sharia Mutual Funds to The Investment Yield Sharia Insurance in Indonesia. The method of research using a causal research design in Indonesia Sharia Insurance. The data used are secondary data sourced from Financial Services Authority, Indonesia. The method of analysis used in this research is the SEM method using SmartPLS software. The results show that Population, Gross Domestic Product, Government Sukuk and Sharia Mutual Funds do not influence Investment Yield Sharia Insurance in Indonesia. The implications of this research are the Indonesian Financial Services Authority policy which considers Population, Gross Domestic Product, Government Sukuk and Sharia Mutual Funds for Investment Yield Sharia Insurance in Indonesia. The limitation of this research is to use monthly samples and only observe for 2 (two) years. Originality of this research is using the latest observation variable that is 2018-2019 and observation at a sharia insurance company in Indonesia.