This paper aims to investigate factors affecting the application of management accounting in Vietnamese enterprises. Quantitative research was conducted and data was collected by sending questionnaires to 120 companies in the manufacturing, trading and service sectors in Vietnam. 6 factors were selected to measure the application of management accounting in enterprises through correlation and regression analysis. The results showed that 5 out of 6 factors positively associated with the level of management accounting application; including firm size, organizational culture, organizational structure, technology and human resources operations. In particular, corporate culture has the highest impact and opinion of managers has the lowest impact on management accounting application. Business environment has a negative impact on management accounting application in enterprises. Based on the research results, suggestions and recommendations are proposed for enterprises regarding application of management accounting. The research provided an overview of management accounting application and its benefits to enterprises. Whereby, it helps managers have a better understanding of management accounting and future directions for application. Moreover, the research results will be useful for managers to identify factors influencing their management accounting practices and improve the current management process applied in organizations.