A simple and environmentally friendly reaction has been developed for the first time for one-pot synthesis of B-amino alcohol derivatives from aromatic phenols, epichlorohydrin and amines by using phase transfer catalysts (PTC) and Aspergillus Oryzae lipase biocatalyst. This method provides access to pharmaceutically relevant products in excellent yields with high regioselectivity. The remarkable catalytic activity and reusability of lipase was possible up to four consecutive cycles.

A series of novel dihydropyrimidin-2(1H)-ones derivatives is synthesized by using Rhizopus Oryzae lipase biocatalyst in deep eutectic solvent. The reaction is characterized by high efficiency and selectivity, short reaction time, mild and environmentally friendly reaction conditions. The yields are found to be significantly higher and reuse of both the lipase and deep eutectic solvent is possible up to four consecutive cycles. The products are found to exhibit appreciable in vitro antibacterial activity against Echerichia coli, Pseudomonas neumoniae and in vitro antifungal activity against Aspergillus niger and Candida albicans.

The aminolytic depolymerization of PET bottle waste with ethanolamine by conventional heating and microwave irradiation heating method was attempted with heterogeneous, recyclable acid catalysts such as beta zeolite (SiO2/ AlO2= 15 Na- form) and montmorillonite KSF. The pure product bis-(2-hydroxyethyl) terephthalamide (BHETA) of aminolysis was obtained in good yield (85- 88%). The BHETA, thus obtained, was subjected to cyclization reaction by heating with polyphosphoric acid as well as by chlorination (using phosphoryl chloride), bromination (using red phosphorous and liquid bromine) and nitration (conc. HNO3 + conc. H2SO4) followed by conventional and microwave irradiation heating in N,N- dimethyl formamide/ potassium carbonate solution. The product so obtained was 2, 2’-(1,4-phenylene)–bis-(2-oxazoline) (PBO), which has applications in polymer synthesis as a chain extender/ chain coupling agent or a cross linker. The productswere analyzed by FTIR, DSC, Mass and NMR (1H and 13C NMR).