The purpose of this study is to examine the determinants of behavioral intentions to use of mobile health (m-Health) applications in Jordan through examining the mediating role of perceived trust and its influence on the behavioral intention to use such applications. A conceptual model was developed based on the extant literature. A questionnaire survey was administered to a convenient sample of 318. Data was analyzed using smart PLS 3. The findings suggest that patients’ behavioral intentions to use m-Health applications are positively affected by perceived ease of use, perceived security, social influence and perceived trust of these applications. Perceived Trust was also found to mediate the relationship between these factors and the behavioral intention. Discussion, conclusions, implications, research limitations and areas for future research are also provided.