In this paper, an integrated production-inventory model with multi-item is developed from the perspectives of single producer, multiple suppliers and retailers. In this three-layer supply chain, the retailers are non-competing. Every supplier delivers only single type of raw material to the producer. The producer manufactures finished goods from the combination of fixed percentage of different types of raw materials. The producer manufactures various types of objects and supplies them to retailers according to the demand of multiple retailers. This paper studies the impact of different types of business policies such as exponential demand rate, demand dependent production rate, optimum order size of raw materials, and unit production cost at each stage of integrated marketing system. Mathematica is used to develop the model and to optimize the integrated profit function. A numerical example and sensitivity analysis is illustrated to justify the feasibility of the proposed model.