This paper focuses on routing flexibility, which is the ability to manufacture a part type via several routes and/or to perform different operations on more than one machine. Specifically, the paper presents a comprehensive method for the measurement of routing flexibility, in a generic manufacturing system. The problem is approached in a modular way, starting from a basic set of flexibility indexes. These are progressively extended to include more comprehensive and complex routing attributes, such as: the average efficiency, the range and the homogeneous distribution of the alternative routes. Two procedures are finally proposed to compare manufacturing systems in terms of routing flexibility. The first one uses a vectorial representation of the previously defined indexes and the second one is based on data envelopment analysis, a multi-criteria decision making approach. The paper concludes with a numerical example, supported by discrete event simulation, which validates the proposed approach.