Even though nowadays the concept of entrepreneurship has become popular in Vietnam, there are a few researches on starting up a business and the factors effect on the desirability of becoming an entrepreneur. The purpose of this study is to examine the effects of entre-preneurial aptitudes, the need of getting higher income and lifestyle on the desirability of starting a business. In the theory and hypothesis section, the principal factors associated with the entrepreneurial desirability are indicated. After that, the overview of entrepreneurship in Vietnam is presented. In addition, by collecting data from 289 students in Vietnam, authors used quantitative analyses by some tools such as such as descriptive statistics, factor analysis, ANOVA test and linear regressions to test the hypothesis of the relationship between entrepreneurial aptitudes, the need of getting higher income and lifestyle with entre-preneurial desirability. As a result, all three independent variables positively affect the Vietnamese students’ desirability of starting a business. Specially, the need of increasing income is seen as the most influential factor on entrepreneurial desirability, followed by lifestyle en-trepreneurial aptitudes.