Today's competition is among supply chains rather than enterprises as independent actors. Additionally, the success of the actors within the SC network, through the improvement of the global performance, depends on how well they handle the growing environmental problems. For this reason, much attention is given to the greening concept. This paper aims to investigate the Green Human Resource Management (GHRM) impact on Green Supply chain Management (GSCM) in a strategic sector, namely the pharmaceutical sector. Our interest to deal with this issue was aroused by the fact that there are no studies exploring the causality relationships in the pharmaceutical sector in Saudi Arabia. Based on deductive methodology, a questionnaire has been developed. A research sample included 109 pharmaceutical companies operating in KSA. The results highlight a significant impact of GHRM on GSCM practices. In other words, training and performance appraisal, recruitment, and eco-behavior-based rewards influence GSCM practices positively. Based on the results, the study provides new theoretical insights and practical suggestions.