Solar panel energy output is an essential parameter for the design and operation of renewable energy systems. Previously, little was known about the precise relationship between the energy outputs of solar panels with various meteorological, radiometric, and weather conditions in the southern California region. Without precise modeling or prediction systems, solar energy can potentially be wasted due to grid energy fluctuation. Thus, it is intended to use an artificial neural network (ANN) to develop solar panel energy output prediction model with a high degree of accuracy. A self-developed feedforward ANN model utilizing the Rectified linear unit (ReLu) activation function was used in the present study. Meteorological, weather, and sun irradiation data collected throughout the last year from a residential location have been used to train the models. The model’s performance was identified based on the minimum mean absolute error (MAE) and root mean square error (RMSE) and maximum linear correlation coefficient (R2). Further, the present self-developed ANN model was consistent with other solar energy experimental results and theoretical analysis. The developed ANN model using the Python programming language achieved a high R2 of more than 85% which ascertains the accuracy and suitability of the model to predict the daily solar energy output in local southern California area. This ANN modeling approach can be extended to many other applications such as SCORE, commercial, and residential building design.