This study aims at investigating the roles of supply chain integration and innovation on supply chain performance through a mediation mechanism of supply chain. This study develops a theoretical framework based on resource-based view and dynamic capability theory. Based on a quantitative study of 214 Saudi hospitals, an empirical analysis was made using a structural equation modelling with AMOS. Results revealed that supply chain integration and innovation positively affect supply chain resilience and performance. In addition, supply chain resilience has a positive and significant relationship with supply chain performance. Most significantly, the relationships of supply chain integration and of innovation to supply chain performance were found to be partially mediated by supply chain resilience. These results showed that integration and innovation have direct effects to improve supply chain performance and indirect ones when hospitals make efforts in developing their resilience. This study is important for top managers of Saudi hospitals to integrate their supply chains and innovate them to improve their resilience and performance.