In this study, an integrated approach is presented for analyzing the impact of resilience engineering and ergonomics factors in aerospace supply chain using data envelopment analysis (DEA). The proposed approach selects the preferred supplier by considering traditional supply chain factors as well as resilience engineering and ergonomics factors. Also, the relevant performance efficiency of each decision making unit is calculated. The case study of this paper is the supply chain of real commercial airlines. Thus, the aerospace standards as well as resilience and ergonomics factors are considered to be modeled by the mathematical programming approach. 22 suppliers are evaluated by analyzing inputs and outputs through data envelopment analysis, and each supplier is considered as a decision making unit (DMU). In this study, the most effective factors are identified as “reliability”, “Human resource management”, “supplier’s delay” and “availability”. Also, “lead time” shows the highest potential for improvement. This study helps decision makers identify the weaknesses of their supply chain management to establish a performance improvement plan in aerospace industry.